92 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17. (2063 aa)
	ENSPTRP00000090552	E3 ubiquitin-protein ligase RNFT1-like. (176 aa)
	STX5	STX5 isoform 1; Belongs to the syntaxin family. (361 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11. (1562 aa)
	IPO11	IPO11 isoform 4. (1015 aa)
	RNFT2	Ring finger protein, transmembrane 2. (444 aa)
	RTKN2	RTKN2 isoform 1. (609 aa)
	MCF2L	MCF2L isoform 9. (1202 aa)
	VANGL1	Vang-like protein. (524 aa)
	VAMP3	Vesicle-associated membrane protein 3 (Cellubrevin). (100 aa)
	PKN2	Protein kinase N2. (984 aa)
	LBR	Lamin B receptor. (615 aa)
	ACBD5	Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters. (534 aa)
	SLK	STE20 like kinase. (1236 aa)
	ARHGAP1	Rho GTPase activating protein 1. (439 aa)
	MCAM	Melanoma cell adhesion molecule. (646 aa)
	ARHGAP32	ARHGAP32 isoform 2. (2095 aa)
	RACGAP1	Rac GTPase activating protein 1. (632 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	ABR	Active BCR-related protein. (840 aa)
	C1QBP	Complement component 1, q subcomponent binding protein. (282 aa)
	JUP	Junction plakoglobin. (745 aa)
	RNFT1	Ring finger protein, transmembrane 1. (435 aa)
	LMAN1	Lectin, mannose-binding, 1. (510 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (968 aa)
	BCAM	Basal cell adhesion molecule (Lutheran blood group). (643 aa)
	RTKN	RTKN isoform 2. (563 aa)
	TGM3	Transglutaminase 3. (693 aa)
	RHOA	Ras homolog family member A. (193 aa)
	DEPDC1B	DEP domain containing 1B. (529 aa)
	ARHGEF28	ARHGEF28 isoform 4. (1731 aa)
	ARHGAP26	Rho GTPase activating protein 26. (814 aa)
	STK10	Serine/threonine kinase 10. (968 aa)
	FLOT1	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
	ARHGAP18	Rho GTPase activating protein 18. (663 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (272 aa)
	ANLN	Anillin, actin binding protein. (1125 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1528 aa)
	ARHGAP39	Rho GTPase activating protein 39. (1114 aa)
	PKN3	Protein kinase N3. (889 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1271 aa)
	AKAP13	A-kinase anchoring protein 13. (2813 aa)
	ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40. (1519 aa)
	TFRC	Transferrin receptor (P90, CD71). (760 aa)
	MACO1	Macoilin; Plays a role in the regulation of neuronal activity. (664 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1589 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1502 aa)
	ARHGEF25	Rho guanine nucleotide exchange factor (GEF) 25. (619 aa)
	VAPB	VAMP (Vesicle-associated membrane protein)-associated protein B and C. (243 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
	CAVIN1	Caveolae associated protein 1. (390 aa)
	CCDC187	Coiled-coil domain containing 187. (2077 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (249 aa)
	MYO9B	LOW QUALITY PROTEIN: unconventional myosin-IXb. (1987 aa)
	ARHGEF10L	ARHGEF10L isoform 1. (1278 aa)
	OLIG1	OLIG1 isoform 2. (272 aa)
	MCF2	MCF2 isoform 7. (1044 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	ERBIN	Erbb2 interacting protein. (1419 aa)
	TJP2	Tight junction protein 2; Belongs to the MAGUK family. (1249 aa)
	ENSPTRP00000065728	annotation not available (516 aa)
	ABCD3	ATP-binding cassette, sub-family D (ALD), member 3. (659 aa)
	ENSPTRP00000066440	annotation not available (232 aa)
	DIAPH3	Diaphanous related formin 3. (1193 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (493 aa)
	TGM6	TGM6 isoform 1. (746 aa)
	OLIG2	OLIG2 isoform 1. (323 aa)
	RHOC	Rho-related GTP-binding protein RhoC isoform X1. (196 aa)
	ARHGEF10	ARHGEF10 isoform 4. (1416 aa)
	LOC739951	Rho GTPase-activating protein 21-like. (1874 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1077 aa)
	ARHGAP35	Glucocorticoid receptor DNA binding factor 1. (1519 aa)
	DIAPH1	DIAPH1 isoform 4. (1278 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (1078 aa)
	PKN1	PKN1 isoform 2. (948 aa)
	ENSPTRP00000079007	annotation not available (323 aa)
	OLIG1-2	OLIG1 isoform 1. (272 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2078 aa)
	STARD13	StAR-related lipid transfer (START) domain containing 13. (1113 aa)
	FMNL3	FMNL3 isoform 2. (1027 aa)
	PREX1	Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1. (1659 aa)
	STOM	STOM isoform 3. (288 aa)
	CK820_G0036362	MCF2L isoform 28. (83 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	ROCK1	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
	FMNL2	FMNL2 isoform 1. (1093 aa)
	MCF2L2	MCF.2 cell line derived transforming sequence-like 2. (1114 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1948 aa)
	MCF2L-2	MCF2L isoform 7. (395 aa)
	OPHN1	Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). (810 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD3	ACBD5	ENSPTRP00000066177	ENSPTRP00000004036	ATP-binding cassette, sub-family D (ALD), member 3.	Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters.	0.684
ABCD3	ANLN	ENSPTRP00000066177	ENSPTRP00000032604	ATP-binding cassette, sub-family D (ALD), member 3.	Anillin, actin binding protein.	0.558
ABCD3	CIT	ENSPTRP00000066177	ENSPTRP00000081274	ATP-binding cassette, sub-family D (ALD), member 3.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.479
ABCD3	FLOT1	ENSPTRP00000066177	ENSPTRP00000030607	ATP-binding cassette, sub-family D (ALD), member 3.	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	0.407
ABCD3	MYO9B	ENSPTRP00000066177	ENSPTRP00000061638	ATP-binding cassette, sub-family D (ALD), member 3.	LOW QUALITY PROTEIN: unconventional myosin-IXb.	0.464
ABCD3	RHOA	ENSPTRP00000066177	ENSPTRP00000025759	ATP-binding cassette, sub-family D (ALD), member 3.	Ras homolog family member A.	0.452
ABCD3	RHOC	ENSPTRP00000066177	ENSPTRP00000071746	ATP-binding cassette, sub-family D (ALD), member 3.	Rho-related GTP-binding protein RhoC isoform X1.	0.452
ABCD3	STOM	ENSPTRP00000066177	ENSPTRP00000083351	ATP-binding cassette, sub-family D (ALD), member 3.	STOM isoform 3.	0.415
ABR	ARHGAP1	ENSPTRP00000014533	ENSPTRP00000006166	Active BCR-related protein.	Rho GTPase activating protein 1.	0.475
ABR	DAAM1	ENSPTRP00000014533	ENSPTRP00000077282	Active BCR-related protein.	Dishevelled associated activator of morphogenesis 1.	0.445
ABR	DAAM2	ENSPTRP00000014533	ENSPTRP00000074068	Active BCR-related protein.	Dishevelled associated activator of morphogenesis 2.	0.445
ABR	MYO9B	ENSPTRP00000014533	ENSPTRP00000061638	Active BCR-related protein.	LOW QUALITY PROTEIN: unconventional myosin-IXb.	0.662
ABR	RHOA	ENSPTRP00000014533	ENSPTRP00000025759	Active BCR-related protein.	Ras homolog family member A.	0.534
ABR	RHOC	ENSPTRP00000014533	ENSPTRP00000071746	Active BCR-related protein.	Rho-related GTP-binding protein RhoC isoform X1.	0.474
ACBD5	ABCD3	ENSPTRP00000004036	ENSPTRP00000066177	Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters.	ATP-binding cassette, sub-family D (ALD), member 3.	0.684
ACBD5	ANLN	ENSPTRP00000004036	ENSPTRP00000032604	Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters.	Anillin, actin binding protein.	0.455
ACBD5	VAPB	ENSPTRP00000004036	ENSPTRP00000057117	Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters.	VAMP (Vesicle-associated membrane protein)-associated protein B and C.	0.909
AKAP13	ARHGEF1	ENSPTRP00000041863	ENSPTRP00000018955	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor 1.	0.937
AKAP13	ARHGEF11	ENSPTRP00000041863	ENSPTRP00000091210	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor (GEF) 11.	0.935
AKAP13	ARHGEF12	ENSPTRP00000041863	ENSPTRP00000058269	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor (GEF) 12.	0.591