STRINGSTRING
CK820_G0025516 CK820_G0025516 KXD1 KXD1 ENSPTRP00000060412 ENSPTRP00000060412 MIB2 MIB2 NCSTN NCSTN NEURL1B NEURL1B LOC452975 LOC452975 PSEN1 PSEN1 ADAM10 ADAM10 MIB1 MIB1 ENSPTRP00000078565 ENSPTRP00000078565 YBX1 YBX1 ENSPTRP00000076001 ENSPTRP00000076001 JAG2 JAG2 LOC104004819 LOC104004819 WWP2 WWP2 DLL4 DLL4 APH1B APH1B EGFR EGFR NOTCH3 NOTCH3 PSENEN PSENEN RPS27A RPS27A JAG1 JAG1 TACC3 TACC3 EGF EGF DLL1 DLL1 APH1A APH1A LOC747903 LOC747903 UBC UBC PSEN2 PSEN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CK820_G0025516YBX1 isoform 1. (320 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060412annotation not available (156 aa)
MIB2Mindbomb homolog 2. (991 aa)
NCSTNNCSTN isoform 1. (721 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (558 aa)
LOC452975Nuclease-sensitive element-binding protein 1 pseudogene. (328 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1014 aa)
ENSPTRP00000078565annotation not available (328 aa)
YBX1YBX1 isoform 3. (295 aa)
ENSPTRP00000076001annotation not available (125 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
LOC104004819Nuclease-sensitive element-binding protein 1 pseudogene. (315 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
PSENENT0105581 isoform 1. (101 aa)
RPS27ARPS27A isoform 1. (156 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (838 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
LOC747903Nuclease-sensitive element-binding protein 1 pseudogene. (306 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.