STRINGSTRING
PSMB2 PSMB2 PSMB4 PSMB4 PSMA1 PSMA1 PSMC3 PSMC3 MAML2 MAML2 PSMD9 PSMD9 PSME1 PSME1 PSME2 PSME2 PSMA6 PSMA6 PSMA3 PSMA3 PSEN1 PSEN1 PSMC1 PSMC1 ADAM10 ADAM10 APH1B APH1B PSMA4 PSMA4 PSMD7 PSMD7 PSMD11 PSMD11 PSMD3 PSMD3 KAT2A KAT2A PSENEN PSENEN PSMD8 PSMD8 RPS27A RPS27A PSMD14 PSMD14 PSMD1 PSMD1 PSMF1 PSMF1 JAG1 JAG1 PSMA7 PSMA7 RBX1 RBX1 EP300 EP300 KAT2B KAT2B PSMD6 PSMD6 PSMD2 PSMD2 TACC3 TACC3 FBXW7 FBXW7 PSMB8 PSMB8 PSMB9 PSMB9 HEY2 HEY2 PSMB1 PSMB1 PSMC2 PSMC2 CUL1 CUL1 PSMB7 PSMB7 NOTCH1 NOTCH1 HES5 HES5 PSMD10 PSMD10 APH1A APH1A FLT4 FLT4 PSMB10 PSMB10 HES4 HES4 CRB1 CRB1 PSMA2 PSMA2 UBC UBC PSEN2 PSEN2 ENSPTRP00000054503 ENSPTRP00000054503 PSMC5 PSMC5 MAML1 MAML1 NOTCH4 NOTCH4 KXD1 KXD1 ENSPTRP00000060300 ENSPTRP00000060300 ENSPTRP00000060412 ENSPTRP00000060412 ENSPTRP00000062484 ENSPTRP00000062484 PSMD5 PSMD5 ENSPTRP00000063316 ENSPTRP00000063316 PSME3-2 PSME3-2 HES1 HES1 ENSPTRP00000064540 ENSPTRP00000064540 NCSTN NCSTN ENSPTRP00000091341 ENSPTRP00000091341 PSMD4 PSMD4 SMAD3 SMAD3 ENSPTRP00000090249 ENSPTRP00000090249 PSMC6 PSMC6 PSMB5 PSMB5 ENSPTRP00000087746 ENSPTRP00000087746 PSMC4 PSMC4 LOC101059795 LOC101059795 ENSPTRP00000086535 ENSPTRP00000086535 CUL1-2 CUL1-2 PSME3 PSME3 ENSPTRP00000085348 ENSPTRP00000085348 ENSPTRP00000084513 ENSPTRP00000084513 AKT1 AKT1 LOC101058095 LOC101058095 ENSPTRP00000082443 ENSPTRP00000082443 ENSPTRP00000082196 ENSPTRP00000082196 ENSPTRP00000081714 ENSPTRP00000081714 MAMLD1-2 MAMLD1-2 HES5-2 HES5-2 CK820_G0002453 CK820_G0002453 PSMA5 PSMA5 MAML3 MAML3 PSMD12 PSMD12 RBPJ RBPJ LOC461963 LOC461963 ENSPTRP00000077985 ENSPTRP00000077985 LOC100611246 LOC100611246 ENSPTRP00000076582 ENSPTRP00000076582 NOTCH2 NOTCH2 SNW1 SNW1 ENSPTRP00000064916 ENSPTRP00000064916 ENSPTRP00000065241 ENSPTRP00000065241 MAMLD1 MAMLD1 ENSPTRP00000067920 ENSPTRP00000067920 PSMB6 PSMB6 HEY1 HEY1 ENSPTRP00000069172 ENSPTRP00000069172 PSMB3 PSMB3 SKP1 SKP1 DLL4 DLL4 LOC470312 LOC470312 PSMD13 PSMD13 ENSPTRP00000071907 ENSPTRP00000071907 ENSPTRP00000073673 ENSPTRP00000073673 YWHAZ YWHAZ ENSPTRP00000074972 ENSPTRP00000074972 CREBBP CREBBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB2Proteasome subunit beta. (201 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMC3Proteasome (Prosome, macropain) 26S subunit, ATPase, 3; Belongs to the AAA ATPase family. (446 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
PSMD9Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 9. (223 aa)
PSME1Proteasome (Prosome, macropain) activator subunit 1 (PA28 alpha). (250 aa)
PSME2Proteasome (Prosome, macropain) activator subunit 2 (PA28 beta). (239 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PSMC1Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; Belongs to the AAA ATPase family. (440 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
PSMA4Proteasome subunit alpha type-4 isoform X2. (261 aa)
PSMD7Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7. (324 aa)
PSMD11Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11. (422 aa)
PSMD3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (534 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
PSENENT0105581 isoform 1. (101 aa)
PSMD8Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 8. (350 aa)
RPS27ARPS27A isoform 1. (156 aa)
PSMD14Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14. (310 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMF1Proteasome (Prosome, macropain) inhibitor subunit 1 (PI31). (271 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
EP300E1A binding protein p300. (2175 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
PSMD6Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6. (441 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (838 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB9Proteasome subunit beta. (218 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMC2Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family. (433 aa)
CUL1CUL1 isoform 1; Belongs to the cullin family. (776 aa)
PSMB7Proteasome subunit beta. (277 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
PSMD10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (226 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PSMB10Proteasome subunit beta type-10. (273 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
ENSPTRP00000054503annotation not available (205 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
MAML1MAML1 isoform 1. (1016 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
KXD1UBA52 isoform 10. (231 aa)
ENSPTRP00000060300annotation not available (221 aa)
ENSPTRP00000060412annotation not available (156 aa)
ENSPTRP00000062484annotation not available (224 aa)
PSMD5PSMD5 isoform 1. (509 aa)
ENSPTRP00000063316annotation not available (235 aa)
PSME3-2Proteasome activator subunit 3. (265 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ENSPTRP00000064540annotation not available (358 aa)
NCSTNNCSTN isoform 1. (721 aa)
ENSPTRP00000091341annotation not available (379 aa)
PSMD4PSMD4 isoform 2. (382 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
ENSPTRP00000090249annotation not available (96 aa)
PSMC6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (411 aa)
PSMB5Proteasome subunit beta. (263 aa)
ENSPTRP00000087746annotation not available (429 aa)
PSMC4Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family. (421 aa)
LOC10105979526S proteasome non-ATPase regulatory subunit 2 pseudogene. (829 aa)
ENSPTRP00000086535annotation not available (351 aa)
CUL1-2Cullin 1. (776 aa)
PSME3Proteasome activator subunit 3. (265 aa)
ENSPTRP00000085348annotation not available (302 aa)
ENSPTRP00000084513annotation not available (205 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
LOC10105809514-3-3 protein zeta/delta pseudogene. (238 aa)
ENSPTRP00000082443annotation not available (351 aa)
ENSPTRP00000082196annotation not available (376 aa)
ENSPTRP00000081714annotation not available (310 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
CK820_G0002453PSMC6 isoform 12. (340 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
MAML3MAML3 isoform 1. (1134 aa)
PSMD12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (480 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
LOC461963PSME2 isoform 10. (224 aa)
ENSPTRP00000077985annotation not available (153 aa)
LOC10061124614-3-3 protein zeta/delta pseudogene. (212 aa)
ENSPTRP00000076582annotation not available (377 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
SNW1SNW domain containing 1. (571 aa)
ENSPTRP00000064916annotation not available (631 aa)
ENSPTRP00000065241annotation not available (350 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
ENSPTRP00000067920annotation not available (392 aa)
PSMB6Proteasome subunit beta. (244 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
ENSPTRP00000069172annotation not available (353 aa)
PSMB3Proteasome subunit beta. (205 aa)
SKP1T0093123 isoform 1; Belongs to the SKP1 family. (163 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
LOC47031226S proteasome regulatory subunit 4 pseudogene. (374 aa)
PSMD13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (399 aa)
ENSPTRP00000071907annotation not available (164 aa)
ENSPTRP00000073673annotation not available (196 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
ENSPTRP00000074972annotation not available (252 aa)
CREBBPCREB binding protein. (2442 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.