Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGO1 | AGO2 | ENSPTRP00000081341 | ENSPTRP00000035263 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.996 |
| AGO1 | AGO3 | ENSPTRP00000081341 | ENSPTRP00000000933 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.938 |
| AGO1 | AGO4 | ENSPTRP00000081341 | ENSPTRP00000044180 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.885 |
| AGO1 | DDX5 | ENSPTRP00000081341 | ENSPTRP00000016210 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | 0.430 |
| AGO1 | HDAC1 | ENSPTRP00000081341 | ENSPTRP00000075891 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.744 |
| AGO1 | HSP90AA1 | ENSPTRP00000081341 | ENSPTRP00000070946 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.724 |
| AGO1 | HSP90AB1 | ENSPTRP00000081341 | ENSPTRP00000031135 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | HSP90AB1 isoform 1. | 0.731 |
| AGO1 | LOC748850 | ENSPTRP00000081341 | ENSPTRP00000067224 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | HDAC2 isoform 9. | 0.551 |
| AGO1 | MOV10 | ENSPTRP00000081341 | ENSPTRP00000001914 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Mov10, Moloney leukemia virus 10, homolog. | 0.913 |
| AGO1 | MYC | ENSPTRP00000081341 | ENSPTRP00000075568 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.536 |
| AGO1 | POLR2A | ENSPTRP00000081341 | ENSPTRP00000042468 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.549 |
| AGO1 | POLR2B | ENSPTRP00000081341 | ENSPTRP00000027669 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.436 |
| AGO1 | POLR2C | ENSPTRP00000081341 | ENSPTRP00000013927 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa. | 0.488 |
| AGO1 | TNRC6A | ENSPTRP00000081341 | ENSPTRP00000047103 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | TNRC6A isoform 3. | 0.998 |
| AGO1 | TNRC6B | ENSPTRP00000081341 | ENSPTRP00000081774 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | TNRC6B isoform 2. | 0.961 |
| AGO1 | TNRC6C | ENSPTRP00000081341 | ENSPTRP00000084787 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | Trinucleotide repeat containing adaptor 6C. | 0.958 |
| AGO2 | AGO1 | ENSPTRP00000035263 | ENSPTRP00000081341 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. | 0.996 |
| AGO2 | AGO3 | ENSPTRP00000035263 | ENSPTRP00000000933 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.979 |
| AGO2 | AGO4 | ENSPTRP00000035263 | ENSPTRP00000044180 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.937 |
| AGO2 | BCL2 | ENSPTRP00000035263 | ENSPTRP00000090293 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | BCL2 apoptosis regulator. | 0.410 |
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