STRINGSTRING
GNG12 GNG12 FGR FGR GNAI3 GNAI3 FCGR1A FCGR1A IL10 IL10 GNG4 GNG4 LOC100612398 LOC100612398 GNG3 GNG3 CD3G CD3G ADCY4 ADCY4 GNB5 GNB5 FURIN FURIN RHBDF1 RHBDF1 ADCY9 ADCY9 DPEP3 DPEP3 DPEP2 DPEP2 DPEP1 DPEP1 ADORA2B ADORA2B RHBDF2 RHBDF2 PRKACA PRKACA CALM3 CALM3 ADCY3 ADCY3 HCK HCK PLCG1 PLCG1 GNAZ GNAZ ITPR2 ITPR2 ITPR1 ITPR1 GNAI2 GNAI2 ADCY5 ADCY5 GNB4 GNB4 PLK2 PLK2 ITPR3 ITPR3 MAPK14 MAPK14 ADCY1 ADCY1 GNGT1 GNGT1 GNG11 GNG11 PRKACG PRKACG GNG10 GNG10 CYSLTR1 CYSLTR1 FCGR2A FCGR2A PRKACB PRKACB CD247 CD247 GNB3 GNB3 PRKAR1A PRKAR1A LYN LYN GGT1 GGT1 ADAM17 ADAM17 GNAT3 GNAT3 GNAS GNAS PRKAR2B PRKAR2B GNGT2 GNGT2 PRKY PRKY LOC100610580 LOC100610580 ADCY7 ADCY7 GNG13 GNG13 ADCY1-2 ADCY1-2 GNG2 GNG2 AHCYL1 AHCYL1 GNB1 GNB1 IL6 IL6 GNG7 GNG7 PRKAR1B PRKAR1B PRKX PRKX GGTLC2 GGTLC2 ENSPTRP00000071036 ENSPTRP00000071036 GNAI1 GNAI1 GGTLC1 GGTLC1 CREB1 CREB1 SYK SYK GGT5 GGT5 PLCG2 PLCG2 SRC SRC ADCY8 ADCY8 FYN FYN MYH9 MYH9 IL6-2 IL6-2 ENSPTRP00000081537 ENSPTRP00000081537 ADCY2 ADCY2 GNB2 GNB2 CD163 CD163 ENSPTRP00000088414 ENSPTRP00000088414 ENSPTRP00000089644 ENSPTRP00000089644 GNG8 GNG8 YES1 YES1 PRKAR2A PRKAR2A CYSLTR2 CYSLTR2 GNB2-2 GNB2-2 ENSPTRP00000093443 ENSPTRP00000093443 ADCY6 ADCY6 CK820_G0040666 CK820_G0040666 LOC749018 LOC749018
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
FGRTyrosine-protein kinase. (529 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
FCGR1AFCGR1A isoform 2. (373 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC100612398SCART1 isoform 2. (1000 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CD3GCD3G isoform 1. (182 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
GNB5GNB5 isoform 1. (409 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
RHBDF1Rhomboid 5 homolog 1. (855 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
DPEP3Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (513 aa)
DPEP2Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (486 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (392 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
RHBDF2RHBDF2 isoform 4. (789 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
HCKTyrosine-protein kinase. (526 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
GNAZG protein subunit alpha z. (355 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
FCGR2ALow affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (By similarity). (318 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CD247CD247 isoform 2. (163 aa)
GNB3G protein subunit beta 3. (340 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
LYNTyrosine-protein kinase. (512 aa)
GGT1GGT1 isoform 21. (225 aa)
ADAM17ADAM17 isoform 3. (999 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
GNASGNAS isoform 19. (1042 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (418 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
PRKYSerine/threonine-protein kinase PRKX. (358 aa)
LOC100610580Glutathione hydrolase light chain 2-like. (225 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ADCY1-2Adenylate cyclase 1. (1119 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
PRKXProtein kinase, X-linked; Belongs to the protein kinase superfamily. (358 aa)
GGTLC2Gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase. (239 aa)
ENSPTRP00000071036annotation not available (68 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
GGTLC1GGT1 isoform 24. (252 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SYKTyrosine-protein kinase. (635 aa)
GGT5Gamma-glutamyltransferase 5. (554 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SRCTyrosine-protein kinase. (542 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
FYNTyrosine-protein kinase. (537 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
IL6-2Interleukin 6. (234 aa)
ENSPTRP00000081537annotation not available (449 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
CD163CD163 isoform 1. (1156 aa)
ENSPTRP00000088414annotation not available (529 aa)
ENSPTRP00000089644annotation not available (335 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
YES1Tyrosine-protein kinase. (558 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (346 aa)
GNB2-2G protein subunit beta 2. (372 aa)
ENSPTRP00000093443annotation not available (57 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CK820_G0040666Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
LOC749018GGT1 isoform 25. (218 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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