(17 nodes) TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling network (Pan troglodytes)

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Your Input:
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	ENSPTRP00000060412	annotation not available (156 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	UBE2NL	Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (153 aa)
	IRAK1-2	Interleukin-1 receptor-associated kinase 1. (712 aa)
	RPS27A	RPS27A isoform 1. (156 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (712 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	ENSPTRP00000077390	annotation not available (132 aa)
	ENSPTRP00000065244	annotation not available (463 aa)
	UBE2N	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	TLR9	T0016681 isoform 1. (1033 aa)
	UBE2N-2	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
	KXD1	UBA52 isoform 10. (231 aa)
	UBC	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (693 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000060412	ENSPTRP00000065244	ENSPTRP00000060412	ENSPTRP00000065244	annotation not available	annotation not available	0.757
ENSPTRP00000060412	ENSPTRP00000077390	ENSPTRP00000060412	ENSPTRP00000077390	annotation not available	annotation not available	0.901
ENSPTRP00000060412	IRAK1	ENSPTRP00000060412	ENSPTRP00000068595	annotation not available	Interleukin 1 receptor associated kinase 1.	0.427
ENSPTRP00000060412	IRAK1-2	ENSPTRP00000060412	ENSPTRP00000038647	annotation not available	Interleukin-1 receptor-associated kinase 1.	0.427
ENSPTRP00000060412	KXD1	ENSPTRP00000060412	ENSPTRP00000060271	annotation not available	UBA52 isoform 10.	0.996
ENSPTRP00000060412	RPS27A	ENSPTRP00000060412	ENSPTRP00000020489	annotation not available	RPS27A isoform 1.	0.952
ENSPTRP00000060412	TRAF6	ENSPTRP00000060412	ENSPTRP00000006096	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.909
ENSPTRP00000060412	UBC	ENSPTRP00000060412	ENSPTRP00000050925	annotation not available	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.993
ENSPTRP00000060412	UBE2N	ENSPTRP00000060412	ENSPTRP00000009000	annotation not available	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.926
ENSPTRP00000060412	UBE2N-2	ENSPTRP00000060412	ENSPTRP00000083269	annotation not available	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.926
ENSPTRP00000060412	UBE2NL	ENSPTRP00000060412	ENSPTRP00000047232	annotation not available	Ubiquitin conjugating enzyme E2 N like (gene/pseudogene).	0.926
ENSPTRP00000065244	ENSPTRP00000060412	ENSPTRP00000065244	ENSPTRP00000060412	annotation not available	annotation not available	0.757
ENSPTRP00000065244	ENSPTRP00000077390	ENSPTRP00000065244	ENSPTRP00000077390	annotation not available	annotation not available	0.732
ENSPTRP00000065244	IRAK1	ENSPTRP00000065244	ENSPTRP00000068595	annotation not available	Interleukin 1 receptor associated kinase 1.	0.855
ENSPTRP00000065244	IRAK1-2	ENSPTRP00000065244	ENSPTRP00000038647	annotation not available	Interleukin-1 receptor-associated kinase 1.	0.855
ENSPTRP00000065244	IRAK4	ENSPTRP00000065244	ENSPTRP00000008285	annotation not available	Interleukin-1 receptor-associated kinase 4.	0.742
ENSPTRP00000065244	IRF7	ENSPTRP00000065244	ENSPTRP00000073107	annotation not available	Interferon regulatory factor 7.	0.708
ENSPTRP00000065244	KXD1	ENSPTRP00000065244	ENSPTRP00000060271	annotation not available	UBA52 isoform 10.	0.673
ENSPTRP00000065244	MYD88	ENSPTRP00000065244	ENSPTRP00000061524	annotation not available	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.836
ENSPTRP00000065244	RPS27A	ENSPTRP00000065244	ENSPTRP00000020489	annotation not available	RPS27A isoform 1.	0.757