8 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	KIF7	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1281 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHH	GLI1	ENSPTRP00000075048	ENSPTRP00000078209	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	GLI family zinc finger 1.	0.731
DHH	GLI2	ENSPTRP00000075048	ENSPTRP00000040313	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	GLI family zinc finger 2.	0.715
DHH	GLI3	ENSPTRP00000075048	ENSPTRP00000032656	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.720
DHH	IHH	ENSPTRP00000075048	ENSPTRP00000022106	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.955
DHH	KIF7	ENSPTRP00000075048	ENSPTRP00000083650	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.553
DHH	SHH	ENSPTRP00000075048	ENSPTRP00000075730	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.956
DHH	SMO	ENSPTRP00000075048	ENSPTRP00000033707	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.793
GLI1	DHH	ENSPTRP00000078209	ENSPTRP00000075048	GLI family zinc finger 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.731
GLI1	GLI2	ENSPTRP00000078209	ENSPTRP00000040313	GLI family zinc finger 1.	GLI family zinc finger 2.	0.992
GLI1	GLI3	ENSPTRP00000078209	ENSPTRP00000032656	GLI family zinc finger 1.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.987
GLI1	IHH	ENSPTRP00000078209	ENSPTRP00000022106	GLI family zinc finger 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.813
GLI1	KIF7	ENSPTRP00000078209	ENSPTRP00000083650	GLI family zinc finger 1.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.861
GLI1	SHH	ENSPTRP00000078209	ENSPTRP00000075730	GLI family zinc finger 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.878
GLI1	SMO	ENSPTRP00000078209	ENSPTRP00000033707	GLI family zinc finger 1.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.902
GLI2	DHH	ENSPTRP00000040313	ENSPTRP00000075048	GLI family zinc finger 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.715
GLI2	GLI1	ENSPTRP00000040313	ENSPTRP00000078209	GLI family zinc finger 2.	GLI family zinc finger 1.	0.992
GLI2	GLI3	ENSPTRP00000040313	ENSPTRP00000032656	GLI family zinc finger 2.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.987
GLI2	IHH	ENSPTRP00000040313	ENSPTRP00000022106	GLI family zinc finger 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.770
GLI2	KIF7	ENSPTRP00000040313	ENSPTRP00000083650	GLI family zinc finger 2.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.862
GLI2	SHH	ENSPTRP00000040313	ENSPTRP00000075730	GLI family zinc finger 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.846