76 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BIRC2	Baculoviral IAP repeat containing 2. (618 aa)
	YAP1	Yes-associated protein 1. (508 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1849 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (711 aa)
	HBE1	Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. (147 aa)
	RAD54L	RAD54L isoform 2. (747 aa)
	ARID3A	ARID3A isoform 1. (590 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
	STAT5A	Signal transducer and activator of transcription. (783 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
	CALR	Calreticulin. (414 aa)
	RAB17	RAB17, member RAS oncogene family. (211 aa)
	MYBL2	V-myb myeloblastosis viral oncogene homolog (Avian)-like 2. (699 aa)
	TOMM34	Translocase of outer mitochondrial membrane 34. (324 aa)
	LOC736246	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (711 aa)
	TOPBP1	Topoisomerase (DNA) II binding protein 1. (1522 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1559 aa)
	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2. (655 aa)
	BAG2	BCL2-associated athanogene 2. (211 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (291 aa)
	STC1	Stanniocalcin 1. (247 aa)
	PXDNL	PXDNL isoform 2. (1463 aa)
	CA9	Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (453 aa)
	XPA	Xeroderma pigmentosum, complementation group A. (273 aa)
	ACSL5	Acyl-CoA synthetase long-chain family member 5. (739 aa)
	TDRD7	Tudor domain containing 7. (1098 aa)
	TFRC	Transferrin receptor (P90, CD71). (760 aa)
	DMAP1	DNA methyltransferase 1-associated protein 1. (467 aa)
	PAX5	PAX5 isoform 1. (391 aa)
	GATA2	GATA binding protein 2. (480 aa)
	KCNN4	Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4. (427 aa)
	TIMP2	CEP295NL isoform 1. (220 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (499 aa)
	BCAT1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
	CDK2	CDK2 isoform 4; Belongs to the protein kinase superfamily. (346 aa)
	JDP2	Jun dimerization protein 2. (175 aa)
	IL6	Interleukin 6 (Interferon, beta 2). (234 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	LOC471880	Histone H2B; Belongs to the histone H2B family. (126 aa)
	TXNRD1	TXNRD1 isoform 3. (648 aa)
	H2BC5	HIST1H2BD isoform 1. (126 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
	UBE2C	Ubiquitin conjugating enzyme E2 C. (203 aa)
	JUND	JUND isoform 1. (346 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	ABCC5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5. (1437 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	IL6-2	Interleukin 6. (234 aa)
	AKAP12	AKAP12 isoform 1. (1780 aa)
	ICAM1	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	ZNF239	ZNF239 isoform 1. (423 aa)
	CCND1	CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (458 aa)
	RELB	RELB isoform 3. (567 aa)
	STAT5B	Signal transducer and activator of transcription. (772 aa)
	KRT8	KRT8 isoform 11; Belongs to the intermediate filament family. (483 aa)
	PXDN	Peroxidasin homolog. (1479 aa)
	ARID1A	AT rich interactive domain 1A (SWI-like). (2287 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
	STAT2	Signal transducer and activator of transcription. (851 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (208 aa)
	PLK1	Serine/threonine-protein kinase PLK. (621 aa)
	CCNB2	CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
	TNFAIP2	Tumor necrosis factor, alpha-induced protein 2. (654 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	ERBB3	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa)
	KRT18	KRT18 isoform 1; Belongs to the intermediate filament family. (430 aa)
	H2AFX	H2AFX isoform 1. (143 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC5	ABCG2	ENSPTRP00000079803	ENSPTRP00000027946	ATP-binding cassette, sub-family C (CFTR/MRP), member 5.	ATP-binding cassette, sub-family G (WHITE), member 2.	0.603
ABCG2	ABCC5	ENSPTRP00000027946	ENSPTRP00000079803	ATP-binding cassette, sub-family G (WHITE), member 2.	ATP-binding cassette, sub-family C (CFTR/MRP), member 5.	0.603
ABCG2	EGFR	ENSPTRP00000027946	ENSPTRP00000069741	ATP-binding cassette, sub-family G (WHITE), member 2.	Receptor protein-tyrosine kinase.	0.508
ABCG2	STAT3	ENSPTRP00000027946	ENSPTRP00000091410	ATP-binding cassette, sub-family G (WHITE), member 2.	Signal transducer and activator of transcription.	0.499
ACSL5	ATP1B3	ENSPTRP00000043677	ENSPTRP00000026646	Acyl-CoA synthetase long-chain family member 5.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.624
AKAP12	BIRC2	ENSPTRP00000082916	ENSPTRP00000007251	AKAP12 isoform 1.	Baculoviral IAP repeat containing 2.	0.496
AKAP12	EGFR	ENSPTRP00000082916	ENSPTRP00000069741	AKAP12 isoform 1.	Receptor protein-tyrosine kinase.	0.591
AKAP12	PLK1	ENSPTRP00000082916	ENSPTRP00000093799	AKAP12 isoform 1.	Serine/threonine-protein kinase PLK.	0.450
AKAP12	RAB17	ENSPTRP00000082916	ENSPTRP00000022374	AKAP12 isoform 1.	RAB17, member RAS oncogene family.	0.441
AKAP12	ZNF239	ENSPTRP00000082916	ENSPTRP00000085956	AKAP12 isoform 1.	ZNF239 isoform 1.	0.441
ARID1A	CCND1	ENSPTRP00000086363	ENSPTRP00000086048	AT rich interactive domain 1A (SWI-like).	CCND1 isoform 1; Belongs to the cyclin family.	0.571
ARID1A	EGFR	ENSPTRP00000086363	ENSPTRP00000069741	AT rich interactive domain 1A (SWI-like).	Receptor protein-tyrosine kinase.	0.465
ARID1A	TOP2A	ENSPTRP00000086363	ENSPTRP00000015554	AT rich interactive domain 1A (SWI-like).	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.446
ARID3A	BCAT1	ENSPTRP00000012453	ENSPTRP00000062905	ARID3A isoform 1.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.408
ARID3A	KCNN4	ENSPTRP00000012453	ENSPTRP00000060256	ARID3A isoform 1.	Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4.	0.451
ARID3A	RAB17	ENSPTRP00000012453	ENSPTRP00000022374	ARID3A isoform 1.	RAB17, member RAS oncogene family.	0.428
ARID3A	RAD54L	ENSPTRP00000012453	ENSPTRP00000001196	ARID3A isoform 1.	RAD54L isoform 2.	0.492
ARID3A	TOMM34	ENSPTRP00000012453	ENSPTRP00000023245	ARID3A isoform 1.	Translocase of outer mitochondrial membrane 34.	0.429
ARID3A	ZNF239	ENSPTRP00000012453	ENSPTRP00000085956	ARID3A isoform 1.	ZNF239 isoform 1.	0.491
ATP1B3	ACSL5	ENSPTRP00000026646	ENSPTRP00000043677	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Acyl-CoA synthetase long-chain family member 5.	0.624