STRINGSTRING
RYK RYK VANGL1 VANGL1 SEMA6C SEMA6C VANGL2 VANGL2 PLXNA2 PLXNA2 WNT11 WNT11 WNT5B WNT5B NANOG NANOG SEMA6B SEMA6B POU5F1 POU5F1 FZD3 FZD3 PLXNA3 PLXNA3 FZD6 FZD6 MAP3K7 MAP3K7 CELSR1 CELSR1 PLXNA4 PLXNA4 PRICKLE2 PRICKLE2 SEMA6A SEMA6A PRICKLE3 PRICKLE3 CELSR3 CELSR3 SEMA6D SEMA6D WNT5A WNT5A CELSR2 CELSR2 PTK7 PTK7 PLXNA1 PLXNA1 PRICKLE1 PRICKLE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYKReceptor like tyrosine kinase. (610 aa)
VANGL1Vang-like protein. (524 aa)
SEMA6CSEMA6C isoform 2; Belongs to the semaphorin family. (962 aa)
VANGL2Vang-like protein. (521 aa)
PLXNA2PLXNA2 isoform 1. (1909 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
SEMA6BSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). (360 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PLXNA3PLXNA3 isoform 1. (1871 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CELSR1CELSR1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2998 aa)
PLXNA4PLXNA4 isoform 1. (1894 aa)
PRICKLE2Prickle planar cell polarity protein 2. (900 aa)
SEMA6ASEMA6A isoform 2; Belongs to the semaphorin family. (1047 aa)
PRICKLE3Prickle planar cell polarity protein 3. (614 aa)
CELSR3Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3322 aa)
SEMA6DSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D; Belongs to the semaphorin family. (1086 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CELSR2CELSR2 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2925 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
PRICKLE1PRICKLE1 isoform 11. (831 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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