STRINGSTRING
DCUN1D1 DCUN1D1 DCUN1D4 DCUN1D4 EGF EGF EXOC2 EXOC2 MAPK14 MAPK14 DLL1 DLL1 EPHB4 EPHB4 SDAD1 SDAD1 AXIN1 AXIN1 SOS2 SOS2 DCUN1D3 DCUN1D3 STAT1 STAT1 EFNB1 EFNB1 WNT5A WNT5A ARAF ARAF MET MET AKT1 AKT1 FBF1 FBF1 TIAM2 TIAM2 LEF1 LEF1 EPHB4-2 EPHB4-2 SRC SRC EGFR EGFR RHOB RHOB FGFR1 FGFR1 MAPKAPK5 MAPKAPK5 DLL3 DLL3 ATF2 ATF2 ACTB ACTB ALB ALB SOS1 SOS1 SHC1 SHC1 MAP3K1 MAP3K1 RABIF RABIF MMP1 MMP1 RPS26 RPS26 RHOF RHOF FLT1 FLT1 SLC7A1 SLC7A1 RHOJ RHOJ COX10 COX10 GRB2 GRB2 GSK3A GSK3A MAPK1 MAPK1 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCUN1D1DCN1-like protein. (259 aa)
DCUN1D4DCN1-like protein. (336 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
EPHB4EPH receptor B4. (987 aa)
SDAD1Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (687 aa)
AXIN1AXIN1 isoform 2. (859 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
DCUN1D3DCN1-like protein. (304 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
EFNB1EFNB1 isoform 1; Belongs to the ephrin family. (346 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
FBF1T0139750 isoform 2. (1181 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1730 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
EPHB4-2EPH receptor B4. (987 aa)
SRCTyrosine-protein kinase. (542 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
RHOBRas homolog gene family, member B. (286 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
MAPKAPK5Mitogen-activated protein kinase-activated protein kinase 5. (487 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
ALBALB isoform 2. (609 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
MAP3K1MAP3K1 isoform 1. (1509 aa)
RABIFRAB interacting factor. (123 aa)
MMP1Matrix metallopeptidase 1 (Interstitial collagenase). (469 aa)
RPS2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
RHOFRas homolog family member F, filopodia associated. (211 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
SLC7A1Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 1. (629 aa)
RHOJRas homolog gene family, member J. (214 aa)
COX10Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. (432 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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