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ZAP70 ZAP70 SIGLEC11 SIGLEC11 CD22 CD22 GRB2 GRB2 IFNG IFNG CBL CBL CD34 CD34 MUC1 MUC1 LCK LCK SOCS3 SOCS3 PIK3C3 PIK3C3 LOC107966154 LOC107966154 ENSPTRP00000089450 ENSPTRP00000089450 TLR9 TLR9 IL5 IL5 SRC SRC CD33 CD33 SYK SYK LEP LEP SIGLEC14 SIGLEC14 TNF TNF ARF6 ARF6 CD40 CD40 ERVFRD-1 ERVFRD-1 CD4 CD4 SIGLEC13 SIGLEC13 SIGLEC8 SIGLEC8 SIGLEC15 SIGLEC15 CD22-2 CD22-2 CRKL CRKL ORM2 ORM2 ENSPTRP00000029460 ENSPTRP00000029460 ST6GAL1 ST6GAL1 SIGLEC1 SIGLEC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZAP70Tyrosine-protein kinase. (619 aa)
SIGLEC11T0182583 isoform 1. (703 aa)
CD22B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
CD34CD34 isoform 1. (328 aa)
MUC1Mucin 1, cell surface associated. (484 aa)
LCKTyrosine-protein kinase. (539 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
LOC107966154SIGLEC8 isoform 2. (499 aa)
ENSPTRP00000089450annotation not available (303 aa)
TLR9T0016681 isoform 1. (1033 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
SRCTyrosine-protein kinase. (542 aa)
CD33CD33 isoform 4. (364 aa)
SYKTyrosine-protein kinase. (635 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
SIGLEC14SIGLEC14 isoform 1. (370 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CD40CD40 molecule, TNF receptor superfamily member 5. (277 aa)
ERVFRD-1Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (By similarity). (538 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
SIGLEC13Sialic acid-binding Ig-like lectin 13; Putative adhesion molecule that mediates sialic-acid dependent binding to cells; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. (387 aa)
SIGLEC8Sialic acid-binding Ig-like lectin 12; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. (597 aa)
SIGLEC15Sialic acid binding Ig like lectin 15. (328 aa)
CD22-2B-cell receptor CD22. (626 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
ORM2Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family. (201 aa)
ENSPTRP00000029460Interleukin 5. (134 aa)
ST6GAL1ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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