STRINGSTRING
CDKN2A CDKN2A INS INS TTR TTR FOXC1 FOXC1 FOXP4-2 FOXP4-2 FOXJ3 FOXJ3 FOXR2 FOXR2 FOXA2 FOXA2 FOXN3 FOXN3 FOXP4 FOXP4 FOXA1 FOXA1 FOXO4 FOXO4 ALB ALB CD4 CD4 FOXC2 FOXC2 FOXG1 FOXG1 FOXD3 FOXD3 FOXF2 FOXF2 FOXK1 FOXK1 FOXP3 FOXP3 AFP AFP IRS1 IRS1 FOXA3 FOXA3 FOXJ1 FOXJ1 FOXN1 FOXN1 FOXL1 FOXL1 FOXF1 FOXF1 IRS2 IRS2 FOXN4 FOXN4 FOXJ2 FOXJ2 FOXR1 FOXR1 PAX7 PAX7 PAX3 PAX3 PIK3C3 PIK3C3 FGF2 FGF2 IGF1 IGF1 FOXP2 FOXP2 FOXP1 FOXP1 SHH SHH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
FOXC1FOXC1 isoform 1. (550 aa)
FOXP4-2Forkhead box P4. (668 aa)
FOXJ3FOXJ3 isoform 1. (622 aa)
FOXR2FOXR2 isoform 1. (311 aa)
FOXA2FOXA2 isoform 1. (464 aa)
FOXN3FOXN3 isoform 2. (490 aa)
FOXP4FOXP4 isoform 3. (668 aa)
FOXA1FOXA1 isoform 1. (471 aa)
FOXO4Forkhead box O4. (505 aa)
ALBALB isoform 2. (609 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
FOXG1FOXG1 isoform 8. (489 aa)
FOXD3FOXD3 isoform 1. (478 aa)
FOXF2FOXF2 isoform 1. (444 aa)
FOXK1FOXK1 isoform 1. (733 aa)
FOXP3FOXP3 isoform 4. (456 aa)
AFPAlpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin; Belongs to the ALB/AFP/VDB family. (622 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
FOXA3FOXA3 isoform 2. (350 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
FOXN1FOXN1 isoform 2. (648 aa)
FOXL1FOXL1 isoform 2. (345 aa)
FOXF1FOXF1 isoform 1. (433 aa)
IRS2IRS2 isoform 1. (1340 aa)
FOXN4FOXN4 isoform 2. (517 aa)
FOXJ2FOXJ2 isoform 1. (573 aa)
FOXR1FOXR1 isoform 1. (292 aa)
PAX7PAX7 isoform 2. (505 aa)
PAX3PAX3 isoform 4. (505 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
FOXP2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (741 aa)
FOXP1FOXP1 isoform 2. (693 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (38%) [HD]