STRINGSTRING
DDIT3 DDIT3 BACH2 BACH2 HDAC3 HDAC3 RASGRP1 RASGRP1 YY1 YY1 BATF BATF CEBPE CEBPE PGR PGR RRAS2 RRAS2 NRAS NRAS ALB ALB ATF3 ATF3 CEBPD CEBPD TBP TBP CEBPB CEBPB FOS FOS JUND JUND
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
BACH2BACH2 isoform 1. (973 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
RASGRP1RASGRP1 isoform 4. (848 aa)
YY1YY1 transcription factor. (414 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa)
RRAS2Related RAS viral (R-ras) oncogene homolog 2. (204 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
ALBALB isoform 2. (609 aa)
ATF3Activating transcription factor 3. (181 aa)
CEBPDCCAAT/enhancer-binding protein. (269 aa)
TBPTBP isoform 1. (336 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
JUNDJUND isoform 1. (346 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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