(15 nodes) (2009) Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate. network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MT1F	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT4	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
	LOC467981	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT1A	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT1G	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT1X	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT2A	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	ALB	ALB isoform 2. (609 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
	MT1H-2	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT1H	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (85 aa)
	MT1M	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (69 aa)
	MT1L	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (79 aa)
	MT1HL1	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSPTRP00000058292	ENSPTRP00000056218	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	ALB isoform 2.	0.755
ALB	ACTB	ENSPTRP00000056218	ENSPTRP00000058292	ALB isoform 2.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.755
ALB	MT1L	ENSPTRP00000056218	ENSPTRP00000080340	ALB isoform 2.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.499
ALB	MT1M	ENSPTRP00000056218	ENSPTRP00000064724	ALB isoform 2.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.499
ALB	TXN	ENSPTRP00000056218	ENSPTRP00000036292	ALB isoform 2.	Thioredoxin; Belongs to the thioredoxin family.	0.465
LOC467981	MT1F	ENSPTRP00000013892	ENSPTRP00000013891	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.466
LOC467981	MT1H-2	ENSPTRP00000013892	ENSPTRP00000061051	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.488
LOC467981	MT1X	ENSPTRP00000013892	ENSPTRP00000013896	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.487
MT1A	MT1H-2	ENSPTRP00000013893	ENSPTRP00000061051	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.568
MT1A	MT1X	ENSPTRP00000013893	ENSPTRP00000013896	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.486
MT1F	LOC467981	ENSPTRP00000013891	ENSPTRP00000013892	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.466
MT1F	MT1H	ENSPTRP00000013891	ENSPTRP00000061538	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.463
MT1F	MT1H-2	ENSPTRP00000013891	ENSPTRP00000061051	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.993
MT1F	MT1HL1	ENSPTRP00000013891	ENSPTRP00000084133	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.746
MT1F	MT1L	ENSPTRP00000013891	ENSPTRP00000080340	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.668
MT1F	MT1M	ENSPTRP00000013891	ENSPTRP00000064724	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.667
MT1F	MT1X	ENSPTRP00000013891	ENSPTRP00000013896	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.997
MT1F	MT2A	ENSPTRP00000013891	ENSPTRP00000027699	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.789
MT1H	MT1F	ENSPTRP00000061538	ENSPTRP00000013891	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.463
MT1H	MT1H-2	ENSPTRP00000061538	ENSPTRP00000061051	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.794