STRINGSTRING
PAK4 PAK4 NRAS NRAS RABIF RABIF CD34 CD34 ERBB3 ERBB3 PLEK2 PLEK2 NF1 NF1 GRB2 GRB2 PLEK PLEK ZAP70 ZAP70 NEU2 NEU2 RHOA RHOA EGF EGF IL2 IL2 IL3 IL3 ESR1 ESR1 GAB3 GAB3 BCR BCR LYN LYN CRKL CRKL PTS PTS CD4 CD4 GAB4 GAB4 FGFR1 FGFR1 FGF2 FGF2 IL6 IL6 EGFR EGFR ERBB2 ERBB2 CSF1 CSF1 NGF NGF PXN PXN HGF HGF PXN-2 PXN-2 SRC SRC CDC42 CDC42 INS INS GAB3-2 GAB3-2 FOS FOS BRAF BRAF IL6-2 IL6-2 JAK2 JAK2 BRAF-2 BRAF-2 ENSPTRP00000089450 ENSPTRP00000089450 FRS2 FRS2 PTEN PTEN STAT3 STAT3 ANGPT1 ANGPT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK4Non-specific serine/threonine protein kinase. (593 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
RABIFRAB interacting factor. (123 aa)
CD34CD34 isoform 1. (328 aa)
ERBB3V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa)
PLEK2PLEK2 isoform 1. (353 aa)
NF1Neurofibromin 1. (2839 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PLEKPLEK isoform 1. (350 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NEU2Neuraminidase 2. (380 aa)
RHOARas homolog family member A. (193 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. (152 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GAB3GRB2 associated binding protein 3. (587 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
LYNTyrosine-protein kinase. (512 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
PTS6-pyruvoyl tetrahydrobiopterin synthase. (145 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
GAB4GAB4 isoform 1. (685 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
PXNPXN isoform 20. (1078 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
PXN-2PXN isoform 9. (1081 aa)
SRCTyrosine-protein kinase. (542 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
GAB3-2GRB2-associated-binding protein 3 isoform X1. (611 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
IL6-2Interleukin 6. (234 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
BRAF-2BRAF isoform 2. (766 aa)
ENSPTRP00000089450annotation not available (303 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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