STRINGSTRING
TMPRSS6 TMPRSS6 SH2B3 SH2B3 BRAP BRAP WDR66 WDR66 PLEK2 PLEK2 ORMDL3 ORMDL3 GSDMA GSDMA CD226 CD226 HAMP HAMP PLEK PLEK FBXO7 FBXO7 MYB MYB TFR2 TFR2 EPO EPO CSF3 CSF3 TPM1 TPM1 PIK3CG PIK3CG DNM3 DNM3 TFRC TFRC BAK1 BAK1 SIRPA SIRPA ATXN2 ATXN2 PRKAR2B PRKAR2B PTPN11 PTPN11 BET1L BET1L THPO THPO ARHGEF3 ARHGEF3 BYSL BYSL SIRT3 SIRT3 CCND3 CCND3 PSMD13 PSMD13 PTPN11-2 PTPN11-2 ENSPTRP00000078404 ENSPTRP00000078404 HFE HFE EPO-2 EPO-2 TAOK1 TAOK1 JAK2 JAK2 EHD3 EHD3 HBS1L HBS1L RUNX1 RUNX1 JMJD1C JMJD1C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
SH2B3SH2B adaptor protein 3. (575 aa)
BRAPBRCA1-associated protein. (592 aa)
WDR66WD repeat domain 66. (1155 aa)
PLEK2PLEK2 isoform 1. (353 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
GSDMAGSDMA isoform 1. (445 aa)
CD226CD226 isoform 1. (336 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
PLEKPLEK isoform 1. (350 aa)
FBXO7F-box protein 7. (522 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
TFR2Transferrin receptor 2. (801 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
CSF3Colony stimulating factor 3 (Granulocyte). (204 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
DNM3DNM3 isoform 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
SIRPASignal-regulatory protein alpha. (504 aa)
ATXN2ATXN2 isoform 2. (1154 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (418 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
BET1LBet1 golgi vesicular membrane trafficking protein like. (92 aa)
THPOTHPO isoform 1. (353 aa)
ARHGEF3Rho guanine nucleotide exchange factor (GEF) 3. (558 aa)
BYSLBYSL isoform 1. (437 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
CCND3CCND3 isoform 1; Belongs to the cyclin family. (292 aa)
PSMD13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (399 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000078404annotation not available (801 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
EPO-2Erythropoietin. (193 aa)
TAOK1TAOK1 isoform 2. (973 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (553 aa)
HBS1LHBS1 like translational GTPase. (698 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
JMJD1CJumonji domain containing 1C. (2540 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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