16 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	DKK1	Dickkopf-like protein 1. (289 aa)
	IFITM3	Interferon induced transmembrane protein 3. (112 aa)
	NANOG	Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	WNT3-2	Wnt family member 3. (290 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	PRDM14	PR/SET domain 14. (571 aa)
	BMP8B	BMP8B isoform 1. (402 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	DKK1	ENSPTRP00000010780	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	NANOG	ENSPTRP00000010780	ENSPTRP00000007892	Bone morphogenetic protein 4.	Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...]	0.554
BMP4	PRDM14	ENSPTRP00000010780	ENSPTRP00000086310	Bone morphogenetic protein 4.	PR/SET domain 14.	0.529
BMP4	SMAD4	ENSPTRP00000010780	ENSPTRP00000017047	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.853
BMP4	SMAD5	ENSPTRP00000010780	ENSPTRP00000080233	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.797
BMP4	SOX2	ENSPTRP00000010780	ENSPTRP00000046752	Bone morphogenetic protein 4.	SRY-box transcription factor 2.	0.566
BMP4	WNT3	ENSPTRP00000010780	ENSPTRP00000015851	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.522
BMP4	WNT3-2	ENSPTRP00000010780	ENSPTRP00000078190	Bone morphogenetic protein 4.	Wnt family member 3.	0.522
BMP4-2	DKK1	ENSPTRP00000080656	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4-2	FGF8	ENSPTRP00000080656	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4-2	NANOG	ENSPTRP00000080656	ENSPTRP00000007892	Bone morphogenetic protein 4.	Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...]	0.554
BMP4-2	PRDM14	ENSPTRP00000080656	ENSPTRP00000086310	Bone morphogenetic protein 4.	PR/SET domain 14.	0.529
BMP4-2	SMAD4	ENSPTRP00000080656	ENSPTRP00000017047	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.853
BMP4-2	SMAD5	ENSPTRP00000080656	ENSPTRP00000080233	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.797
BMP4-2	SOX2	ENSPTRP00000080656	ENSPTRP00000046752	Bone morphogenetic protein 4.	SRY-box transcription factor 2.	0.566
BMP4-2	WNT3	ENSPTRP00000080656	ENSPTRP00000015851	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.522
BMP4-2	WNT3-2	ENSPTRP00000080656	ENSPTRP00000078190	Bone morphogenetic protein 4.	Wnt family member 3.	0.522
BMP8B	SMAD4	ENSPTRP00000001003	ENSPTRP00000017047	BMP8B isoform 1.	Mothers against decapentaplegic homolog.	0.435
BMP8B	SMAD5	ENSPTRP00000001003	ENSPTRP00000080233	BMP8B isoform 1.	Mothers against decapentaplegic homolog.	0.428