STRINGSTRING
BMP8B BMP8B BMP4-2 BMP4-2 PRDM14 PRDM14 WNT3-2 WNT3-2 SMAD5 SMAD5 FGF8 FGF8 SOX2 SOX2 TGFB1 TGFB1 SMAD4 SMAD4 WNT3 WNT3 TGFB3 TGFB3 BMP4 BMP4 NANOG NANOG IFITM3 IFITM3 DKK1 DKK1 TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP8BBMP8B isoform 1. (402 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
PRDM14PR/SET domain 14. (571 aa)
WNT3-2Wnt family member 3. (290 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SOX2SRY-box transcription factor 2. (319 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
IFITM3Interferon induced transmembrane protein 3. (112 aa)
DKK1Dickkopf-like protein 1. (289 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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