STRINGSTRING
JAK2 JAK2 CRK CRK FGF10 FGF10 VAV2 VAV2 FGF6 FGF6 FGF20 FGF20 GAB3-2 GAB3-2 INS INS FYN FYN SRC SRC FGF8 FGF8 HGF HGF CSF1 CSF1 IL6 IL6 FGF13 FGF13 FGFR1 FGFR1 FGF22 FGF22 INSR INSR GAB4 GAB4 GATA2 GATA2 MDM4 MDM4 CRKL CRKL LYN LYN FGF16 FGF16 FGF17 FGF17 BCR BCR GAB3 GAB3 FGF1 FGF1 IL3 IL3 EGF EGF FGF5 FGF5 RHOA RHOA E2F1 E2F1 PLEK PLEK FGF21 FGF21 GRB2 GRB2 FGF7 FGF7 PLEK2 PLEK2 FGF14 FGF14 FLT3 FLT3 FGF9 FGF9 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 ENSPTRP00000089450 ENSPTRP00000089450 FGF11 FGF11 FGF12 FGF12 E2F1-2 E2F1-2 STAT3 STAT3 FGF18 FGF18 IL6-2 IL6-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK2Tyrosine-protein kinase. (1143 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GAB3-2GRB2-associated-binding protein 3 isoform X1. (611 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
FYNTyrosine-protein kinase. (537 aa)
SRCTyrosine-protein kinase. (542 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
GAB4GAB4 isoform 1. (685 aa)
GATA2GATA binding protein 2. (480 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
LYNTyrosine-protein kinase. (512 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
GAB3GRB2 associated binding protein 3. (587 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. (152 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
RHOARas homolog family member A. (193 aa)
E2F1E2F transcription factor 1. (437 aa)
PLEKPLEK isoform 1. (350 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PLEK2PLEK2 isoform 1. (353 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSPTRP00000089450annotation not available (303 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
E2F1-2E2F transcription factor 1. (437 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IL6-2Interleukin 6. (234 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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