STRINGSTRING
NUMBL NUMBL ITGB1 ITGB1 ITGB8 ITGB8 CTSH CTSH COX6B1 COX6B1 BIN1 BIN1 FKBP1A FKBP1A EEF1A2 EEF1A2 CCNG1 CCNG1 EEF1A1 EEF1A1 NUMB NUMB FLNC FLNC ITGB5 ITGB5 DYSF DYSF LOC453361 LOC453361 INSR INSR FLNA FLNA ITGB2 ITGB2 FKBP1A-2 FKBP1A-2 FLNB FLNB AK1 AK1 TEAD2 TEAD2 ITGB4 ITGB4 TEAD3 TEAD3 RPL5 RPL5 MYL2 MYL2 AMPD1 AMPD1 NOTCH2 NOTCH2 PVALB PVALB ITGB7 ITGB7 GAPDH GAPDH TEAD4 TEAD4 DUPD1 DUPD1 CASQ1 CASQ1 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUMBLNUMBL isoform 1. (611 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
CTSHCTSH isoform 11; Belongs to the peptidase C1 family. (335 aa)
COX6B1Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
BIN1Bridging integrator 1. (597 aa)
FKBP1APeptidylprolyl isomerase. (139 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
CCNG1CCNG1 isoform 2; Belongs to the cyclin family. (295 aa)
EEF1A1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
FLNCFilamin C, gamma. (2725 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
DYSFDYSF isoform 8. (2119 aa)
LOC453361CAPN3 isoform 4; Belongs to the peptidase C2 family. (821 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
FLNAFLNA isoform 8. (2711 aa)
ITGB2Integrin beta. (863 aa)
FKBP1A-2FK506 binding protein 1A, 12kDa. (91 aa)
FLNBFilamin B, beta. (2633 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
ITGB4Integrin beta. (1822 aa)
TEAD3TEA domain transcription factor 3. (435 aa)
RPL5Ribosomal protein L5. (302 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
PVALBPVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
DUPD1Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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