(18 nodes) (2012) Modulator of Apoptosis 1: A Highly Regulated RASSF1A-Interacting BH3-Like Protein. network (Pan troglodytes)

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Your Input:
	LOC107972317	Cytochrome c-like. (102 aa)
	YAP1	Yes-associated protein 1. (508 aa)
	PNMA1	Paraneoplastic antigen MA1. (353 aa)
	LMNB2	LMNB2 isoform 1; Belongs to the intermediate filament family. (620 aa)
	CASP8	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
	RASSF6	Ras association domain family member 6. (369 aa)
	LMNB1-2	LMNB1 isoform 1; Belongs to the intermediate filament family. (586 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	PNMA5	PNMA family member 5. (448 aa)
	RPP21	E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similari [...] (518 aa)
	MAFB	V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	MOAP1	Modulator of apoptosis 1. (351 aa)
	ENSPTRP00000063547	Cytochrome c. (105 aa)
	LOC104002760	Cytochrome c. (110 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	LOC742456	Cytochrome c-like. (105 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CASP3	ENSPTRP00000090293	ENSPTRP00000054330	BCL2 apoptosis regulator.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.895
BCL2	CASP8	ENSPTRP00000090293	ENSPTRP00000021879	BCL2 apoptosis regulator.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.906
BCL2	CYCS	ENSPTRP00000090293	ENSPTRP00000032465	BCL2 apoptosis regulator.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.984
BCL2	ENSPTRP00000063547	ENSPTRP00000090293	ENSPTRP00000063547	BCL2 apoptosis regulator.	Cytochrome c.	0.850
BCL2	LOC104002760	ENSPTRP00000090293	ENSPTRP00000082320	BCL2 apoptosis regulator.	Cytochrome c.	0.983
BCL2	LOC107972317	ENSPTRP00000090293	ENSPTRP00000064294	BCL2 apoptosis regulator.	Cytochrome c-like.	0.976
BCL2	LOC742456	ENSPTRP00000090293	ENSPTRP00000093429	BCL2 apoptosis regulator.	Cytochrome c-like.	0.985
BCL2	STAT1	ENSPTRP00000090293	ENSPTRP00000090934	BCL2 apoptosis regulator.	Signal transducer and activator of transcription.	0.560
BCL2	YAP1	ENSPTRP00000090293	ENSPTRP00000007247	BCL2 apoptosis regulator.	Yes-associated protein 1.	0.471
CASP3	BCL2	ENSPTRP00000054330	ENSPTRP00000090293	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	BCL2 apoptosis regulator.	0.895
CASP3	CASP8	ENSPTRP00000054330	ENSPTRP00000021879	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.997
CASP3	CYCS	ENSPTRP00000054330	ENSPTRP00000032465	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.988
CASP3	ENSPTRP00000063547	ENSPTRP00000054330	ENSPTRP00000063547	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cytochrome c.	0.887
CASP3	LMNB1-2	ENSPTRP00000054330	ENSPTRP00000029399	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	LMNB1 isoform 1; Belongs to the intermediate filament family.	0.605
CASP3	LMNB2	ENSPTRP00000054330	ENSPTRP00000017403	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	LMNB2 isoform 1; Belongs to the intermediate filament family.	0.644
CASP3	LOC104002760	ENSPTRP00000054330	ENSPTRP00000082320	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cytochrome c.	0.986
CASP3	LOC107972317	ENSPTRP00000054330	ENSPTRP00000064294	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cytochrome c-like.	0.980
CASP3	LOC742456	ENSPTRP00000054330	ENSPTRP00000093429	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cytochrome c-like.	0.988
CASP3	STAT1	ENSPTRP00000054330	ENSPTRP00000090934	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.569
CASP8	BCL2	ENSPTRP00000021879	ENSPTRP00000090293	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	BCL2 apoptosis regulator.	0.906