7 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HESX1	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
	FGFR1	Fibroblast growth factor receptor. (854 aa)
	TLE1	Transducin-like enhancer of split 1. (814 aa)
	CHD7	CHD7 isoform 1. (2997 aa)
	PRL	PRL isoform 1. (227 aa)
	PROP1	PROP paired-like homeobox 1. (226 aa)
	GNRHR	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHD7	FGFR1	ENSPTRP00000034725	ENSPTRP00000065828	CHD7 isoform 1.	Fibroblast growth factor receptor.	0.592
CHD7	GNRHR	ENSPTRP00000034725	ENSPTRP00000027689	CHD7 isoform 1.	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.627
CHD7	HESX1	ENSPTRP00000034725	ENSPTRP00000025986	CHD7 isoform 1.	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	0.500
FGFR1	CHD7	ENSPTRP00000065828	ENSPTRP00000034725	Fibroblast growth factor receptor.	CHD7 isoform 1.	0.592
FGFR1	GNRHR	ENSPTRP00000065828	ENSPTRP00000027689	Fibroblast growth factor receptor.	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.646
GNRHR	CHD7	ENSPTRP00000027689	ENSPTRP00000034725	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	CHD7 isoform 1.	0.627
GNRHR	FGFR1	ENSPTRP00000027689	ENSPTRP00000065828	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	Fibroblast growth factor receptor.	0.646
GNRHR	HESX1	ENSPTRP00000027689	ENSPTRP00000025986	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	0.459
GNRHR	PRL	ENSPTRP00000027689	ENSPTRP00000030340	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	PRL isoform 1.	0.493
GNRHR	PROP1	ENSPTRP00000027689	ENSPTRP00000030054	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	PROP paired-like homeobox 1.	0.439
HESX1	CHD7	ENSPTRP00000025986	ENSPTRP00000034725	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	CHD7 isoform 1.	0.500
HESX1	GNRHR	ENSPTRP00000025986	ENSPTRP00000027689	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.459
HESX1	PRL	ENSPTRP00000025986	ENSPTRP00000030340	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	PRL isoform 1.	0.493
HESX1	TLE1	ENSPTRP00000025986	ENSPTRP00000045296	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	Transducin-like enhancer of split 1.	0.563
PRL	GNRHR	ENSPTRP00000030340	ENSPTRP00000027689	PRL isoform 1.	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.493
PRL	HESX1	ENSPTRP00000030340	ENSPTRP00000025986	PRL isoform 1.	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	0.493
PRL	PROP1	ENSPTRP00000030340	ENSPTRP00000030054	PRL isoform 1.	PROP paired-like homeobox 1.	0.750
PROP1	GNRHR	ENSPTRP00000030054	ENSPTRP00000027689	PROP paired-like homeobox 1.	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.439
PROP1	PRL	ENSPTRP00000030054	ENSPTRP00000030340	PROP paired-like homeobox 1.	PRL isoform 1.	0.750
PROP1	TLE1	ENSPTRP00000030054	ENSPTRP00000045296	PROP paired-like homeobox 1.	Transducin-like enhancer of split 1.	0.491