51 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Your Input:
	PGK1	Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (459 aa)
	RPS18	Ribosomal protein S18; Belongs to the universal ribosomal protein uS13 family. (152 aa)
	PDCL2	Phosducin like 2. (241 aa)
	PROM1	PROM1 isoform 12. (865 aa)
	FXR1	Fragile X mental retardation, autosomal homolog 1. (782 aa)
	GAP43	Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (274 aa)
	CCK	CCK isoform 2. (115 aa)
	GLS	GLS isoform 1. (669 aa)
	NOTCH3	NOTCH3 isoform 1. (2321 aa)
	EEF2	Eukaryotic translation elongation factor 2. (858 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	FXR2	Fragile X mental retardation, autosomal homolog 2. (673 aa)
	RBM19	RNA binding motif protein 19. (961 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	GLB1L2	Beta-galactosidase. (636 aa)
	EMX2	Empty spiracles homeobox 2. (252 aa)
	ANK3	ANK3 isoform 5. (4377 aa)
	MAGOH	Mago-nashi homolog, proliferation-associated. (146 aa)
	PVALB	PVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
	CUX2	Homeobox protein cut-like. (1489 aa)
	PTBP2	Polypyrimidine tract binding protein 2. (543 aa)
	ENSPTRP00000087266	Phosphoglycerate kinase 1. (394 aa)
	FOXP4-2	Forkhead box P4. (668 aa)
	GLB1	Beta-galactosidase. (699 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	DEPDC5	DEP domain containing 5. (1605 aa)
	FEZF2	FEZ family zinc finger 2. (463 aa)
	FMR1	Fragile X mental retardation 1. (632 aa)
	NUMB	NUMB endocytic adaptor protein. (651 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	GLB1L3	Beta-galactosidase. (653 aa)
	NOVA2	NOVA alternative splicing regulator 2. (492 aa)
	FOXG1	FOXG1 isoform 8. (489 aa)
	SPHKAP	SPHK1 interactor, AKAP domain containing. (1700 aa)
	RELN	RELN isoform 3. (3460 aa)
	EMX1	Empty spiracles homeobox 1. (290 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
	LOC462608	Ribosomal protein S18 pseudogene. (152 aa)
	FOXP4	FOXP4 isoform 3. (668 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1386 aa)
	NUMBL	NUMBL isoform 1. (611 aa)
	ETF1	Eukaryotic translation termination factor 1. (423 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (526 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
	ENSPTRP00000071028	annotation not available (152 aa)
	FOXP2	Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (741 aa)
	TLE4	TLE family member 4, transcriptional corepressor. (805 aa)
	ETF1-2	Eukaryotic translation termination factor 1. (381 aa)
	RPS13	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
	ADA	Adenosine deaminase. (412 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CCK	ENSPTRP00000058292	ENSPTRP00000025499	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CCK isoform 2.	0.553
ACTB	EEF2	ENSPTRP00000058292	ENSPTRP00000017487	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Eukaryotic translation elongation factor 2.	0.507
ACTB	EIF4E	ENSPTRP00000058292	ENSPTRP00000069083	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.418
ACTB	ENSPTRP00000087266	ENSPTRP00000058292	ENSPTRP00000087266	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Phosphoglycerate kinase 1.	0.600
ACTB	GAPDH	ENSPTRP00000058292	ENSPTRP00000007822	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Glyceraldehyde-3-phosphate dehydrogenase.	0.896
ACTB	PGK1	ENSPTRP00000058292	ENSPTRP00000031205	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.	0.432
ACTB	PROM1	ENSPTRP00000058292	ENSPTRP00000027438	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	PROM1 isoform 12.	0.439
ACTB	RPS6KB1	ENSPTRP00000058292	ENSPTRP00000016085	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.484
ANK3	GAPDH	ENSPTRP00000004348	ENSPTRP00000007822	ANK3 isoform 5.	Glyceraldehyde-3-phosphate dehydrogenase.	0.493
ANK3	SPHKAP	ENSPTRP00000004348	ENSPTRP00000055619	ANK3 isoform 5.	SPHK1 interactor, AKAP domain containing.	0.449
CCK	ACTB	ENSPTRP00000025499	ENSPTRP00000058292	CCK isoform 2.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.553
CCK	GAPDH	ENSPTRP00000025499	ENSPTRP00000007822	CCK isoform 2.	Glyceraldehyde-3-phosphate dehydrogenase.	0.682
CCK	PVALB	ENSPTRP00000025499	ENSPTRP00000075273	CCK isoform 2.	PVALB isoform 1; Belongs to the parvalbumin family.	0.641
CUX2	EMX1	ENSPTRP00000089985	ENSPTRP00000057829	Homeobox protein cut-like.	Empty spiracles homeobox 1.	0.469
CUX2	FEZF2	ENSPTRP00000089985	ENSPTRP00000079962	Homeobox protein cut-like.	FEZ family zinc finger 2.	0.604
CUX2	PAX6	ENSPTRP00000089985	ENSPTRP00000065705	Homeobox protein cut-like.	PAX6 isoform 13.	0.454
CUX2	TBR1	ENSPTRP00000089985	ENSPTRP00000046292	Homeobox protein cut-like.	T-box brain transcription factor 1.	0.498
DEPDC5	PPP3CB	ENSPTRP00000081581	ENSPTRP00000064667	DEP domain containing 5.	Serine/threonine-protein phosphatase.	0.569
DEPDC5	SPHKAP	ENSPTRP00000081581	ENSPTRP00000055619	DEP domain containing 5.	SPHK1 interactor, AKAP domain containing.	0.624
EEF2	ACTB	ENSPTRP00000017487	ENSPTRP00000058292	Eukaryotic translation elongation factor 2.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.507