STRINGSTRING
INSR INSR CRK CRK GRB2 GRB2 INS INS FYN FYN SRC SRC IGF1 IGF1 BRCA1 BRCA1 CDX2 CDX2 BRCA2 BRCA2 IRS2 IRS2 IRS4 IRS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSRTyrosine-protein kinase receptor. (1408 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
FYNTyrosine-protein kinase. (537 aa)
SRCTyrosine-protein kinase. (542 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
CDX2Caudal type homeobox 2. (313 aa)
BRCA2Breast cancer 2, early onset. (3418 aa)
IRS2IRS2 isoform 1. (1340 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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