STRINGSTRING
CTNNB1 CTNNB1 USF1 USF1 SIRT1 SIRT1 HRAS HRAS OTX2 OTX2 AMH AMH GAD1 GAD1 DLX2 DLX2 BMP7 BMP7 GTF2I GTF2I LHX2 LHX2 PCDH11X PCDH11X FMR1 FMR1 ELP4 ELP4 FOXG1 FOXG1 APOE APOE SMAD9 SMAD9 DLX6 DLX6 CMIP CMIP CK820_G0054728 CK820_G0054728 CNTNAP2 CNTNAP2 ENSPTRP00000064802 ENSPTRP00000064802 RUNX2 RUNX2 MEF2A MEF2A FOXP2 FOXP2 PVALB PVALB FGF8 FGF8 SHH SHH AR AR USF2 USF2 CITED2 CITED2 MECP2 MECP2 GTF2I-2 GTF2I-2 WNT5A WNT5A PTEN PTEN ROBO2 ROBO2 ELAVL2 ELAVL2 SIRT1-2 SIRT1-2 APP APP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
USF1Upstream transcription factor 1. (310 aa)
SIRT1SIRT1 isoform 2. (751 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
AMHAnti-Mullerian hormone. (560 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (594 aa)
DLX2Distal-less homeobox 2. (328 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GTF2IGeneral transcription factor IIi. (998 aa)
LHX2LHX2 isoform 1. (406 aa)
PCDH11XProtocadherin-11 X-linked; Potential calcium-dependent cell-adhesion protein. (1347 aa)
FMR1Fragile X mental retardation 1. (632 aa)
ELP4ELP4 isoform 9. (534 aa)
FOXG1FOXG1 isoform 8. (489 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
DLX6DLX6 isoform 1. (295 aa)
CMIPC-Maf-inducing protein. (744 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
ENSPTRP00000064802Protocadherin-11 X-linked. (1099 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
FOXP2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (741 aa)
PVALBPVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
USF2Upstream transcription factor 2, c-fos interacting. (336 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
GTF2I-2General transcription factor IIi. (998 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
ELAVL2ELAV-like protein; Belongs to the RRM elav family. (395 aa)
SIRT1-2Sirtuin 1. (751 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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