23 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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protein homology

Your Input:
	BMP6	Bone morphogenetic protein 6. (512 aa)
	ADIPOR1	Adiponectin receptor 1. (375 aa)
	NENF	Neuron derived neurotrophic factor; Belongs to the cytochrome b5 family. (172 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
	ZNHIT2	Zinc finger, HIT-type containing 2. (403 aa)
	ALDOC	Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	PRDX2	PRDX2 isoform 1. (198 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	CTSB	CTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
	ERP44	Endoplasmic reticulum protein 44. (406 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (652 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
	ADIPOR2	Adiponectin receptor 2. (386 aa)
	APOB	APOB isoform 1. (4562 aa)
	PDIA5	Protein disulfide isomerase family A member 5. (519 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	PDIA6	PDIA6 isoform 2; Belongs to the protein disulfide isomerase family. (489 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
	BLOC1S5	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (220 aa)
	CDK5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
	DNAJC10	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (822 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	INS	ENSPTRP00000026385	ENSPTRP00000077843	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.400
ADIPOQ	ADIPOR1	ENSPTRP00000027045	ENSPTRP00000003118	Adiponectin, C1Q and collagen domain containing.	Adiponectin receptor 1.	0.997
ADIPOQ	ADIPOR2	ENSPTRP00000027045	ENSPTRP00000044848	Adiponectin, C1Q and collagen domain containing.	Adiponectin receptor 2.	0.997
ADIPOQ	APOB	ENSPTRP00000027045	ENSPTRP00000052150	Adiponectin, C1Q and collagen domain containing.	APOB isoform 1.	0.587
ADIPOQ	ERP44	ENSPTRP00000027045	ENSPTRP00000036210	Adiponectin, C1Q and collagen domain containing.	Endoplasmic reticulum protein 44.	0.471
ADIPOQ	INS	ENSPTRP00000027045	ENSPTRP00000077843	Adiponectin, C1Q and collagen domain containing.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.773
ADIPOQ	TNF	ENSPTRP00000027045	ENSPTRP00000069905	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.724
ADIPOR1	ADIPOQ	ENSPTRP00000003118	ENSPTRP00000027045	Adiponectin receptor 1.	Adiponectin, C1Q and collagen domain containing.	0.997
ADIPOR1	ADIPOR2	ENSPTRP00000003118	ENSPTRP00000044848	Adiponectin receptor 1.	Adiponectin receptor 2.	0.996
ADIPOR1	INS	ENSPTRP00000003118	ENSPTRP00000077843	Adiponectin receptor 1.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.564
ADIPOR1	NR4A1	ENSPTRP00000003118	ENSPTRP00000039485	Adiponectin receptor 1.	Nuclear receptor subfamily 4 group A member 1.	0.572
ADIPOR2	ADIPOQ	ENSPTRP00000044848	ENSPTRP00000027045	Adiponectin receptor 2.	Adiponectin, C1Q and collagen domain containing.	0.997
ADIPOR2	ADIPOR1	ENSPTRP00000044848	ENSPTRP00000003118	Adiponectin receptor 2.	Adiponectin receptor 1.	0.996
ADIPOR2	INS	ENSPTRP00000044848	ENSPTRP00000077843	Adiponectin receptor 2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.520
ADIPOR2	PDIA6	ENSPTRP00000044848	ENSPTRP00000076612	Adiponectin receptor 2.	PDIA6 isoform 2; Belongs to the protein disulfide isomerase family.	0.404
ALDOC	NENF	ENSPTRP00000015230	ENSPTRP00000003303	Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family.	Neuron derived neurotrophic factor; Belongs to the cytochrome b5 family.	0.565
ALDOC	ZNHIT2	ENSPTRP00000015230	ENSPTRP00000006663	Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family.	Zinc finger, HIT-type containing 2.	0.442
APOB	ADIPOQ	ENSPTRP00000052150	ENSPTRP00000027045	APOB isoform 1.	Adiponectin, C1Q and collagen domain containing.	0.587
APOB	DNAJC10	ENSPTRP00000052150	ENSPTRP00000088198	APOB isoform 1.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.412
APOB	INS	ENSPTRP00000052150	ENSPTRP00000077843	APOB isoform 1.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.674