20 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	DKK1	Dickkopf-like protein 1. (289 aa)
	GLB1L2	Beta-galactosidase. (636 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	MSX2	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity); Belongs to the Msh homeobox family. (267 aa)
	FOXH1	FOXH1 isoform 1. (365 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	GLB1L3	Beta-galactosidase. (653 aa)
	FOXH1-2	Forkhead box H1. (365 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	WNT3-2	Wnt family member 3. (290 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	MSX1	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	GLB1	Beta-galactosidase. (699 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	DKK1	ENSPTRP00000010780	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4	DLX1	ENSPTRP00000010780	ENSPTRP00000039172	Bone morphogenetic protein 4.	Distal-less homeobox 1.	0.406
BMP4	LEF1	ENSPTRP00000010780	ENSPTRP00000079959	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.626
BMP4	MSX1	ENSPTRP00000010780	ENSPTRP00000055966	Bone morphogenetic protein 4.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.682
BMP4	MSX2	ENSPTRP00000010780	ENSPTRP00000029971	Bone morphogenetic protein 4.	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity); Belongs to the Msh homeobox family.	0.614
BMP4	PAX6	ENSPTRP00000010780	ENSPTRP00000065705	Bone morphogenetic protein 4.	PAX6 isoform 13.	0.475
BMP4	SMAD2	ENSPTRP00000010780	ENSPTRP00000062376	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.730
BMP4	WNT3	ENSPTRP00000010780	ENSPTRP00000015851	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.522
BMP4	WNT3-2	ENSPTRP00000010780	ENSPTRP00000078190	Bone morphogenetic protein 4.	Wnt family member 3.	0.522
BMP4-2	DKK1	ENSPTRP00000080656	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4-2	DLX1	ENSPTRP00000080656	ENSPTRP00000039172	Bone morphogenetic protein 4.	Distal-less homeobox 1.	0.406
BMP4-2	LEF1	ENSPTRP00000080656	ENSPTRP00000079959	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.626
BMP4-2	MSX1	ENSPTRP00000080656	ENSPTRP00000055966	Bone morphogenetic protein 4.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.682
BMP4-2	MSX2	ENSPTRP00000080656	ENSPTRP00000029971	Bone morphogenetic protein 4.	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity); Belongs to the Msh homeobox family.	0.614
BMP4-2	PAX6	ENSPTRP00000080656	ENSPTRP00000065705	Bone morphogenetic protein 4.	PAX6 isoform 13.	0.475
BMP4-2	SMAD2	ENSPTRP00000080656	ENSPTRP00000062376	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.730
BMP4-2	WNT3	ENSPTRP00000080656	ENSPTRP00000015851	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.522
BMP4-2	WNT3-2	ENSPTRP00000080656	ENSPTRP00000078190	Bone morphogenetic protein 4.	Wnt family member 3.	0.522
DKK1	BMP4	ENSPTRP00000004327	ENSPTRP00000010780	Dickkopf-like protein 1.	Bone morphogenetic protein 4.	0.566
DKK1	BMP4-2	ENSPTRP00000004327	ENSPTRP00000080656	Dickkopf-like protein 1.	Bone morphogenetic protein 4.	0.566