13 items (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SRC	Tyrosine-protein kinase. (542 aa)
	HCK	Tyrosine-protein kinase. (526 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (408 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	HCFC2	Host cell factor C2. (792 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
	CD81	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] (303 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	CD63	Tetraspanin. (238 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	HCFC1	Host cell factor C1. (2080 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD63	CD81	ENSPTRP00000008613	ENSPTRP00000074537	Tetraspanin.	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	0.840
CD63	EGFR	ENSPTRP00000008613	ENSPTRP00000069741	Tetraspanin.	Receptor protein-tyrosine kinase.	0.730
CD63	GAPDH	ENSPTRP00000008613	ENSPTRP00000007822	Tetraspanin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.595
CD81	CD63	ENSPTRP00000074537	ENSPTRP00000008613	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	Tetraspanin.	0.840
CD81	CLDN1	ENSPTRP00000074537	ENSPTRP00000027073	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.986
CD81	EGFR	ENSPTRP00000074537	ENSPTRP00000069741	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	Receptor protein-tyrosine kinase.	0.789
CD81	GAPDH	ENSPTRP00000074537	ENSPTRP00000007822	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.608
CD81	LYN	ENSPTRP00000074537	ENSPTRP00000046608	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	Tyrosine-protein kinase.	0.581
CLDN1	CD81	ENSPTRP00000027073	ENSPTRP00000074537	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	0.986
CLDN1	EGFR	ENSPTRP00000027073	ENSPTRP00000069741	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Receptor protein-tyrosine kinase.	0.767
CLDN1	GAPDH	ENSPTRP00000027073	ENSPTRP00000007822	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.488
CLDN1	SRC	ENSPTRP00000027073	ENSPTRP00000076797	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tyrosine-protein kinase.	0.463
EGFR	CD63	ENSPTRP00000069741	ENSPTRP00000008613	Receptor protein-tyrosine kinase.	Tetraspanin.	0.730
EGFR	CD81	ENSPTRP00000069741	ENSPTRP00000074537	Receptor protein-tyrosine kinase.	CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]	0.789
EGFR	CLDN1	ENSPTRP00000069741	ENSPTRP00000027073	Receptor protein-tyrosine kinase.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.767
EGFR	GAPDH	ENSPTRP00000069741	ENSPTRP00000007822	Receptor protein-tyrosine kinase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.901
EGFR	GRB2	ENSPTRP00000069741	ENSPTRP00000016382	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.999
EGFR	HCK	ENSPTRP00000069741	ENSPTRP00000022925	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.799
EGFR	LYN	ENSPTRP00000069741	ENSPTRP00000046608	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.853
EGFR	MYC	ENSPTRP00000069741	ENSPTRP00000075568	Receptor protein-tyrosine kinase.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.738