8 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LCN2	Lipocalin 2. (240 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	LCN2-2	LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
	IFNB1	Interferon beta 1. (187 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	CCN2	CTGF isoform 1. (349 aa)
	IL6-2	Interleukin 6. (234 aa)
	IL6	Interleukin 6 (Interferon, beta 2). (234 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCN2	IL6	ENSPTRP00000090133	ENSPTRP00000068252	CTGF isoform 1.	Interleukin 6 (Interferon, beta 2).	0.481
CCN2	IL6-2	ENSPTRP00000090133	ENSPTRP00000080270	CTGF isoform 1.	Interleukin 6.	0.481
CCN2	TP53	ENSPTRP00000090133	ENSPTRP00000014836	CTGF isoform 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.417
IFNB1	IL6	ENSPTRP00000035597	ENSPTRP00000068252	Interferon beta 1.	Interleukin 6 (Interferon, beta 2).	0.744
IFNB1	IL6-2	ENSPTRP00000035597	ENSPTRP00000080270	Interferon beta 1.	Interleukin 6.	0.744
IFNB1	TP53	ENSPTRP00000035597	ENSPTRP00000014836	Interferon beta 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.516
IL6	CCN2	ENSPTRP00000068252	ENSPTRP00000090133	Interleukin 6 (Interferon, beta 2).	CTGF isoform 1.	0.481
IL6	IFNB1	ENSPTRP00000068252	ENSPTRP00000035597	Interleukin 6 (Interferon, beta 2).	Interferon beta 1.	0.744
IL6	IL6-2	ENSPTRP00000068252	ENSPTRP00000080270	Interleukin 6 (Interferon, beta 2).	Interleukin 6.	0.543
IL6	LCN2	ENSPTRP00000068252	ENSPTRP00000070420	Interleukin 6 (Interferon, beta 2).	Lipocalin 2.	0.608
IL6	LCN2-2	ENSPTRP00000068252	ENSPTRP00000048884	Interleukin 6 (Interferon, beta 2).	LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family.	0.609
IL6	TP53	ENSPTRP00000068252	ENSPTRP00000014836	Interleukin 6 (Interferon, beta 2).	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.514
IL6-2	CCN2	ENSPTRP00000080270	ENSPTRP00000090133	Interleukin 6.	CTGF isoform 1.	0.481
IL6-2	IFNB1	ENSPTRP00000080270	ENSPTRP00000035597	Interleukin 6.	Interferon beta 1.	0.744
IL6-2	IL6	ENSPTRP00000080270	ENSPTRP00000068252	Interleukin 6.	Interleukin 6 (Interferon, beta 2).	0.543
IL6-2	LCN2	ENSPTRP00000080270	ENSPTRP00000070420	Interleukin 6.	Lipocalin 2.	0.608
IL6-2	LCN2-2	ENSPTRP00000080270	ENSPTRP00000048884	Interleukin 6.	LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family.	0.609
IL6-2	TP53	ENSPTRP00000080270	ENSPTRP00000014836	Interleukin 6.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.514
LCN2	IL6	ENSPTRP00000070420	ENSPTRP00000068252	Lipocalin 2.	Interleukin 6 (Interferon, beta 2).	0.608
LCN2	IL6-2	ENSPTRP00000070420	ENSPTRP00000080270	Lipocalin 2.	Interleukin 6.	0.608