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ADORA2A ADORA2A DNMT3L DNMT3L DSCAM DSCAM E2F1 E2F1 HIST1H3A HIST1H3A EDAR EDAR NCK2 NCK2 UCN UCN SIRT2 SIRT2 TOM1L1 TOM1L1 KAT2A KAT2A ADAM10 ADAM10 SPTLC2 SPTLC2 PSEN1 PSEN1 CFL2 CFL2 SP1 SP1 H2AFX H2AFX NNMT NNMT CDK2AP2 CDK2AP2 TNKS2 TNKS2 TET1 TET1 SIRT1 SIRT1 H3-4 H3-4 MTHFR MTHFR EDARADD EDARADD PICALM PICALM DNMT3B DNMT3B GSK3B GSK3B BMI1 BMI1 STX1B STX1B LOC107966300 LOC107966300 BLCAP BLCAP UBE3A UBE3A DROSHA DROSHA CD33 CD33 TET3 TET3 PTBP1 PTBP1 HDAC1 HDAC1 TNKS TNKS CREBBP CREBBP HDAC4 HDAC4 CDK2AP1 CDK2AP1 CA12 CA12 EIF4E EIF4E IRAK1 IRAK1 TET2 TET2 IGF1 IGF1 HTT HTT CYFIP2 CYFIP2 FLNA FLNA INSR INSR ABCA7 ABCA7 SHMT2 SHMT2 GFAP GFAP ND6 ND6 ND4L ND4L ND2 ND2 ND5 ND5 ND4 ND4 BDNF BDNF SPTLC3 SPTLC3 ATXN1 ATXN1 APOE APOE SETDB1 SETDB1 S100A2 S100A2 PSEN2 PSEN2 HDAC2 HDAC2 H3C13 H3C13 FLNC FLNC TERF1 TERF1 COG3 COG3 APP APP SIRT1-2 SIRT1-2 YTHDF1 YTHDF1 AICDA AICDA SNCA SNCA E2F1-2 E2F1-2 BCL2 BCL2 FLNB FLNB CFL1 CFL1 PTBP2 PTBP2 ACHE ACHE FGF20 FGF20 SP3 SP3 HDAC11 HDAC11 CD2AP CD2AP CLUL1 CLUL1 YTHDF3 YTHDF3 ANK1 ANK1 MAP2 MAP2 IRAK1-2 IRAK1-2 AGO2 AGO2 CLU CLU SORBS3 SORBS3 PRKN PRKN WTAP WTAP BAG2 BAG2 XPO5 XPO5 TREM2 TREM2 LOC112209457 LOC112209457 NR3C1 NR3C1 HDAC3 HDAC3 GRIA2 GRIA2 METTL14 METTL14 NCK1 NCK1 PRKCD PRKCD KAT2B KAT2B EP300 EP300 PISD PISD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
DNMT3LT0078603 isoform 1. (387 aa)
DSCAMDS cell adhesion molecule. (2012 aa)
E2F1E2F transcription factor 1. (437 aa)
HIST1H3AH3F3B isoform 13. (136 aa)
EDAREctodysplasin A receptor. (496 aa)
NCK2Cytoplasmic protein. (380 aa)
UCNUCN isoform 1. (124 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
TOM1L1Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (476 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
SPTLC2Serine palmitoyltransferase, long chain base subunit 2. (564 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CFL2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
SP1Sp1 transcription factor. (786 aa)
H2AFXH2AFX isoform 1. (143 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
CDK2AP2Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (126 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
TET1TET1 isoform 1. (2136 aa)
SIRT1SIRT1 isoform 2. (751 aa)
H3-4HIST3H3 isoform 1. (136 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (656 aa)
EDARADDEDAR associated death domain. (215 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (674 aa)
DNMT3BDNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
BMI1BMI1 isoform 1. (326 aa)
STX1BSTX1B isoform 1; Belongs to the syntaxin family. (278 aa)
LOC107966300Histone H3. (136 aa)
BLCAPBladder cancer associated protein. (87 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
DROSHADrosha, ribonuclease type III. (1380 aa)
CD33CD33 isoform 4. (364 aa)
TET3TET3 isoform 2. (1797 aa)
PTBP1PTBP1 isoform 2. (680 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
CREBBPCREB binding protein. (2442 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
CDK2AP1Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (134 aa)
CA12Carbonic anhydrase XII; Belongs to the alpha-carbonic anhydrase family. (354 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
TET2TET2 isoform 1. (2023 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
HTTHTT isoform 1. (3131 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
FLNAFLNA isoform 8. (2711 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
ABCA7ABCA7 isoform 3. (1829 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (174 aa)
ND4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (98 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (603 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (459 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
SPTLC3Serine palmitoyltransferase, long chain base subunit 3. (552 aa)
ATXN1ATXN1 isoform 2. (827 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
SETDB1SETDB1 isoform 4. (1292 aa)
S100A2Protein S100; Belongs to the S-100 family. (98 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
H3C13HIST2H3A isoform 1. (136 aa)
FLNCFilamin C, gamma. (2725 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (439 aa)
COG3Component of oligomeric golgi complex 3. (828 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
SIRT1-2Sirtuin 1. (751 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (584 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
E2F1-2E2F transcription factor 1. (437 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
FLNBFilamin B, beta. (2633 aa)
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
PTBP2Polypyrimidine tract binding protein 2. (543 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SP3Sp3 transcription factor. (781 aa)
HDAC11HDAC11 isoform 14. (374 aa)
CD2APCD2-associated protein. (650 aa)
CLUL1Clusterin; Belongs to the clusterin family. (524 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
ANK1ANK1 isoform 1. (1897 aa)
MAP2Microtubule-associated protein. (1827 aa)
IRAK1-2Interleukin-1 receptor-associated kinase 1. (712 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (878 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
SORBS3Sorbin and SH3 domain containing 3. (671 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
WTAPWilms tumor 1 associated protein. (396 aa)
BAG2BCL2-associated athanogene 2. (211 aa)
XPO5XPO5 isoform 1. (1204 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LOC112209457HIST1H3A isoform 1. (136 aa)
NR3C1NR3C1 isoform 5. (778 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
NCK1Cytoplasmic protein. (377 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
EP300E1A binding protein p300. (2175 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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