STRINGSTRING
IGF2 IGF2 MTOR MTOR FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 TUBA1A TUBA1A FGF9 FGF9 FGF14 FGF14 FGF7 FGF7 FGF21 FGF21 PROM1 PROM1 FGF5 FGF5 FGF1 FGF1 DLL1 DLL1 FGF17 FGF17 FGF16 FGF16 INSC INSC ASPM ASPM TUBB3 TUBB3 ADGRG1 ADGRG1 RELN RELN FLNA FLNA PAX6 PAX6 FGF22 FGF22 FGF13 FGF13 DMD DMD FGF8 FGF8 SHH SHH ASCL1 ASCL1 ARFGEF2 ARFGEF2 FGF10 FGF10 DMD-2 DMD-2 FGF6 FGF6 FGF20 FGF20 CCND1 CCND1 FGF11 FGF11 FGF12 FGF12 TRNP1 TRNP1 FGF18 FGF18 PIK3C3 PIK3C3 MCPH1 MCPH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGF2Insulin like growth factor 2. (236 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
TUBA1ADetyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). (451 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PROM1PROM1 isoform 12. (865 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INSCINSC spindle orientation adaptor protein. (579 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (797 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
RELNRELN isoform 3. (3460 aa)
FLNAFLNA isoform 8. (2711 aa)
PAX6PAX6 isoform 13. (436 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
DMDDMD isoform 3. (3685 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (Brefeldin A-inhibited). (1792 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DMD-2Dystrophin. (643 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
TRNP1TMF1-regulated nuclear protein 1. (227 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
MCPH1Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). (851 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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