STRINGSTRING
MTOR MTOR STAT5B STAT5B STAT1 STAT1 STAT3 STAT3 STAT2 STAT2 GRB2 GRB2 ABI1 ABI1 ALB ALB ERVFRD-1 ERVFRD-1 TNF TNF TGFBR1 TGFBR1 SRC SRC STAT4 STAT4 ROCK1 ROCK1 STAT5A STAT5A STAT6 STAT6 CBL CBL CD34 CD34
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ABI1Abl interactor 1. (508 aa)
ALBALB isoform 2. (609 aa)
ERVFRD-1Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (By similarity). (538 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SRCTyrosine-protein kinase. (542 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
CD34CD34 isoform 1. (328 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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