38 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	STAT5A	Signal transducer and activator of transcription. (783 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	OTP	Orthopedia homeobox. (325 aa)
	COL10A1	Collagen type X alpha 1 chain. (680 aa)
	HOXA11	HOXA11 isoform 2. (313 aa)
	CTSB	CTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
	CTSL	CTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
	ASPN	Asporin. (378 aa)
	COL2A1	Collagen type II alpha 1 chain. (1487 aa)
	ADRB3	ADRB3 isoform 1. (408 aa)
	SOX6	SOX6 isoform 9. (828 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
	HOXA9-2	Homeobox protein Hox-A9. (272 aa)
	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1. (493 aa)
	SHOX	Short stature homeobox. (292 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	HOXA9	Homeobox A9. (272 aa)
	POSTN	POSTN isoform 2. (865 aa)
	HOXD9	HOXD9 isoform 1. (356 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	CTSS	CTSS isoform 1; Belongs to the peptidase C1 family. (331 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	DCN	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (359 aa)
	SOX5	SRY (Sex determining region Y)-box 5. (765 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	STAT2	Signal transducer and activator of transcription. (851 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	CCN2	CTGF isoform 1. (349 aa)
	FOXA2	FOXA2 isoform 1. (464 aa)
	LOC473484	Cathepsin L1. (276 aa)
	FGFR3	Fibroblast growth factor receptor. (808 aa)
	STAT5B	Signal transducer and activator of transcription. (772 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPN	CCN2	ENSPTRP00000036080	ENSPTRP00000090133	Asporin.	CTGF isoform 1.	0.407
ASPN	COL10A1	ENSPTRP00000036080	ENSPTRP00000031636	Asporin.	Collagen type X alpha 1 chain.	0.438
ASPN	COL2A1	ENSPTRP00000036080	ENSPTRP00000041995	Asporin.	Collagen type II alpha 1 chain.	0.608
ASPN	DCN	ENSPTRP00000036080	ENSPTRP00000008989	Asporin.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.540
ASPN	EFEMP1	ENSPTRP00000036080	ENSPTRP00000068385	Asporin.	EGF-containing fibulin-like extracellular matrix protein 1.	0.528
ASPN	OTP	ENSPTRP00000036080	ENSPTRP00000029132	Asporin.	Orthopedia homeobox.	0.402
ASPN	POSTN	ENSPTRP00000036080	ENSPTRP00000078181	Asporin.	POSTN isoform 2.	0.720
BMP4	CCN2	ENSPTRP00000010780	ENSPTRP00000090133	Bone morphogenetic protein 4.	CTGF isoform 1.	0.510
BMP4	FGF4	ENSPTRP00000010780	ENSPTRP00000006879	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.640
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	IHH	ENSPTRP00000010780	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4	RUNX2	ENSPTRP00000010780	ENSPTRP00000065999	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.732
BMP4	RUNX3	ENSPTRP00000010780	ENSPTRP00000000614	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.414
BMP4	SOX9	ENSPTRP00000010780	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
BMP4-2	CCN2	ENSPTRP00000080656	ENSPTRP00000090133	Bone morphogenetic protein 4.	CTGF isoform 1.	0.510
BMP4-2	FGF4	ENSPTRP00000080656	ENSPTRP00000006879	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.640
BMP4-2	FGF8	ENSPTRP00000080656	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4-2	IHH	ENSPTRP00000080656	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4-2	RUNX2	ENSPTRP00000080656	ENSPTRP00000065999	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.732
BMP4-2	RUNX3	ENSPTRP00000080656	ENSPTRP00000000614	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.414