STRINGSTRING
NANOG NANOG GSTM1 GSTM1 SDK2 SDK2 EFNB1 EFNB1 ITGB8-2 ITGB8-2 ITGB8 ITGB8 BICC1 BICC1 ID4 ID4 PAX6 PAX6 ENSPTRP00000065099 ENSPTRP00000065099 RSPO2 RSPO2 INSR INSR COL4A2 COL4A2 NFIB NFIB MYT1L MYT1L FOXG1 FOXG1 NFIA NFIA APOLD1 APOLD1 GLI3 GLI3 NEUROD6 NEUROD6 SLC35F1 SLC35F1 SEMA5A SEMA5A CDH4 CDH4 ZNF516 ZNF516 OTX2 OTX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
GSTM1GSTM1 isoform 3; Belongs to the GST superfamily. (218 aa)
SDK2SDK2 isoform 1. (2172 aa)
EFNB1EFNB1 isoform 1; Belongs to the ephrin family. (346 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
BICC1Bicaudal C homolog 1. (1074 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
PAX6PAX6 isoform 13. (436 aa)
ENSPTRP00000065099annotation not available (337 aa)
RSPO2R-spondin 2 homolog. (243 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
MYT1LMyelin transcription factor 1 like. (1185 aa)
FOXG1FOXG1 isoform 8. (489 aa)
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (554 aa)
APOLD1Apolipoprotein L domain containing 1. (279 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
SLC35F1Solute carrier family 35 member F1. (408 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
CDH4CDH4 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
ZNF516Zinc finger protein 516. (1163 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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