16 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VCL	VCL isoform 2. (1134 aa)
	SCN1B	Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
	ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9. (1549 aa)
	PXN-2	PXN isoform 9. (1081 aa)
	TLN1	TLN1 isoform 1. (2558 aa)
	PXN	PXN isoform 20. (1078 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
	RYR2	RYR2 isoform 1. (4941 aa)
	SCN10A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
	KCNE1	KCNE1B isoform 1. (132 aa)
	DSG2	DSG2 isoform 1. (1118 aa)
	JUP	Junction plakoglobin. (745 aa)
	TLN2	TLN2 isoform 1. (2544 aa)
	PKP2	PKP2 isoform 1. (837 aa)
	SCN3B	Sodium voltage-gated channel beta subunit 3. (215 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC9	CASQ2	ENSPTRP00000084549	ENSPTRP00000001966	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.492
ABCC9	DSG2	ENSPTRP00000084549	ENSPTRP00000016915	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	DSG2 isoform 1.	0.604
ABCC9	JUP	ENSPTRP00000084549	ENSPTRP00000015634	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	Junction plakoglobin.	0.415
ABCC9	PKP2	ENSPTRP00000084549	ENSPTRP00000008236	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	PKP2 isoform 1.	0.506
ABCC9	RYR2	ENSPTRP00000084549	ENSPTRP00000064508	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	RYR2 isoform 1.	0.424
ABCC9	SCN10A	ENSPTRP00000084549	ENSPTRP00000042609	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.448
ABCC9	SCN1B	ENSPTRP00000084549	ENSPTRP00000089848	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.	0.538
ABCC9	SCN3B	ENSPTRP00000084549	ENSPTRP00000007545	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	Sodium voltage-gated channel beta subunit 3.	0.527
ABCC9	SCN5A	ENSPTRP00000084549	ENSPTRP00000069526	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.646
CASQ2	ABCC9	ENSPTRP00000001966	ENSPTRP00000084549	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	0.492
CASQ2	DSG2	ENSPTRP00000001966	ENSPTRP00000016915	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	DSG2 isoform 1.	0.434
CASQ2	JUP	ENSPTRP00000001966	ENSPTRP00000015634	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Junction plakoglobin.	0.459
CASQ2	KCNE1	ENSPTRP00000001966	ENSPTRP00000023886	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	KCNE1B isoform 1.	0.422
CASQ2	PKP2	ENSPTRP00000001966	ENSPTRP00000008236	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	PKP2 isoform 1.	0.524
CASQ2	RYR2	ENSPTRP00000001966	ENSPTRP00000064508	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	RYR2 isoform 1.	0.991
CASQ2	SCN1B	ENSPTRP00000001966	ENSPTRP00000089848	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.	0.413
CASQ2	SCN5A	ENSPTRP00000001966	ENSPTRP00000069526	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.605
DSG2	ABCC9	ENSPTRP00000016915	ENSPTRP00000084549	DSG2 isoform 1.	ATP-binding cassette, sub-family C (CFTR/MRP), member 9.	0.604
DSG2	CASQ2	ENSPTRP00000016915	ENSPTRP00000001966	DSG2 isoform 1.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.434
DSG2	JUP	ENSPTRP00000016915	ENSPTRP00000015634	DSG2 isoform 1.	Junction plakoglobin.	0.964