20 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FMNL1	FMNL1 isoform 1. (1100 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
	SLC2A4	SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (466 aa)
	KRT7	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells; Belongs to the intermediate filament family. (469 aa)
	CFL1	CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
	CDC42	Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	DIAPH1	DIAPH1 isoform 4. (1278 aa)
	FMN2	FMN2 isoform 6. (198 aa)
	RPS20	Ribosomal protein S20. (142 aa)
	MAL2	Mal, T cell differentiation protein 2. (176 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
	RHOA	Ras homolog family member A. (193 aa)
	OXTR	Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
	COMT	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (271 aa)
	CFL2	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
	SLC2A3	Solute carrier family 2 (Facilitated glucose transporter), member 3; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (496 aa)
	VWF	Von Willebrand factor. (2813 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CDC42	ENSPTRP00000058292	ENSPTRP00000077648	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.955
ACTB	CFL1	ENSPTRP00000058292	ENSPTRP00000087369	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CFL1 isoform 2; Belongs to the actin-binding proteins ADF family.	0.993
ACTB	CFL2	ENSPTRP00000058292	ENSPTRP00000010616	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.	0.984
ACTB	FYN	ENSPTRP00000058292	ENSPTRP00000077482	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase.	0.498
ACTB	NOS3	ENSPTRP00000058292	ENSPTRP00000034022	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Nitric oxide synthase; Produces nitric oxide (NO).	0.603
ACTB	RHOA	ENSPTRP00000058292	ENSPTRP00000025759	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Ras homolog family member A.	0.958
ACTB	SLC2A4	ENSPTRP00000058292	ENSPTRP00000014790	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.402
ACTB	SRC	ENSPTRP00000058292	ENSPTRP00000076797	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase.	0.541
CDC42	ACTB	ENSPTRP00000077648	ENSPTRP00000058292	Cell division cycle 42 (GTP binding protein, 25kDa).	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.955
CDC42	CFL1	ENSPTRP00000077648	ENSPTRP00000087369	Cell division cycle 42 (GTP binding protein, 25kDa).	CFL1 isoform 2; Belongs to the actin-binding proteins ADF family.	0.780
CDC42	CFL2	ENSPTRP00000077648	ENSPTRP00000010616	Cell division cycle 42 (GTP binding protein, 25kDa).	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.	0.761
CDC42	DIAPH1	ENSPTRP00000077648	ENSPTRP00000075718	Cell division cycle 42 (GTP binding protein, 25kDa).	DIAPH1 isoform 4.	0.689
CDC42	FMN2	ENSPTRP00000077648	ENSPTRP00000072717	Cell division cycle 42 (GTP binding protein, 25kDa).	FMN2 isoform 6.	0.426
CDC42	FMNL1	ENSPTRP00000077648	ENSPTRP00000015809	Cell division cycle 42 (GTP binding protein, 25kDa).	FMNL1 isoform 1.	0.992
CDC42	FYN	ENSPTRP00000077648	ENSPTRP00000077482	Cell division cycle 42 (GTP binding protein, 25kDa).	Tyrosine-protein kinase.	0.970
CDC42	MAL2	ENSPTRP00000077648	ENSPTRP00000066248	Cell division cycle 42 (GTP binding protein, 25kDa).	Mal, T cell differentiation protein 2.	0.653
CDC42	RHOA	ENSPTRP00000077648	ENSPTRP00000025759	Cell division cycle 42 (GTP binding protein, 25kDa).	Ras homolog family member A.	0.950
CDC42	SRC	ENSPTRP00000077648	ENSPTRP00000076797	Cell division cycle 42 (GTP binding protein, 25kDa).	Tyrosine-protein kinase.	0.980
CFL1	ACTB	ENSPTRP00000087369	ENSPTRP00000058292	CFL1 isoform 2; Belongs to the actin-binding proteins ADF family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.993
CFL1	CDC42	ENSPTRP00000087369	ENSPTRP00000077648	CFL1 isoform 2; Belongs to the actin-binding proteins ADF family.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.780