STRINGSTRING
CNTN2 CNTN2 PDGFRB PDGFRB FEZF2 FEZF2 PRKAB2 PRKAB2 NEFL NEFL NOTCH2 NOTCH2 ID4 ID4 CHD1L CHD1L DLL4 DLL4 EGFR EGFR FGF2 FGF2 PAX6 PAX6 MAGI3 MAGI3 SOX1 SOX1 UNC5D UNC5D FOXG1 FOXG1 SOX10 SOX10 TBR1 TBR1 SRGAP2 SRGAP2 BCL11B BCL11B DLX1 DLX1 SVIP SVIP SEMA3A SEMA3A DLL1 DLL1 LOC738370 LOC738370 EGF EGF GAP43 GAP43 SIX3 SIX3 NOTCH3 NOTCH3 NOG NOG VTN VTN FGFR2 FGFR2 DKK1 DKK1 GJA8 GJA8 ACP6 ACP6 FMO5 FMO5 GPR89A GPR89A TXNIP TXNIP PDE4DIP PDE4DIP SOX3 SOX3 BRD9 BRD9 GJA5 GJA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNTN2CNTN2 isoform 13. (1040 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FEZF2FEZ family zinc finger 2. (463 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
CHD1LChromodomain helicase DNA binding protein 1-like. (925 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
PAX6PAX6 isoform 13. (436 aa)
MAGI3MAGI3 isoform 1. (1266 aa)
SOX1SOX1 isoform 1. (391 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
FOXG1FOXG1 isoform 8. (489 aa)
SOX10SRY-box transcription factor 10. (466 aa)
TBR1T-box brain transcription factor 1. (682 aa)
SRGAP2SRGAP2 isoform 1. (1071 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
DLX1Distal-less homeobox 1. (255 aa)
SVIPSmall VCP/p97-interacting protein. (77 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
LOC738370Bromodomain containing 9. (596 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAP43Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (274 aa)
SIX3SIX homeobox 3. (331 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
VTNVTN isoform 1. (478 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
DKK1Dickkopf-like protein 1. (289 aa)
GJA8Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (433 aa)
ACP6Acid phosphatase 6, lysophosphatidic; Belongs to the histidine acid phosphatase family. (428 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
GPR89AG protein-coupled receptor 89A. (455 aa)
TXNIPArrestin_C domain-containing protein. (391 aa)
PDE4DIPPDE4DIP isoform 9. (2319 aa)
SOX3SRY-box transcription factor 3. (446 aa)
BRD9BRD9 isoform 8. (600 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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