STRINGSTRING
MUC1 MUC1 STAT2 STAT2 STAT3 STAT3 STAT1 STAT1 CD44 CD44 STAT5B STAT5B ST3GAL6 ST3GAL6 FUT9 FUT9 EPCAM EPCAM JAK2 JAK2 FUT1 FUT1 CD24 CD24 BMP4-2 BMP4-2 LOC107968591 LOC107968591 STAT4 STAT4 GALNT14 GALNT14 LIFR LIFR GLI1 GLI1 SHH SHH MYC MYC CREB1 CREB1 LMO2 LMO2 CCNA1 CCNA1 EGFR EGFR FGF2 FGF2 FGFR1 FGFR1 PAX6 PAX6 OGA OGA GALNT6 GALNT6 APOB APOB WNT3A WNT3A KLF4 KLF4 GMDS GMDS CCNA2 CCNA2 ST6GAL1 ST6GAL1 LIF LIF GALNT3 GALNT3 MGAT5 MGAT5 GALNT1 GALNT1 SOX9 SOX9 STAT5A STAT5A BMP4 BMP4 STAT6 STAT6 NANOG NANOG B4GALT3 B4GALT3 LMNA LMNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MUC1Mucin 1, cell surface associated. (484 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
CD44CD44 isoform 3. (742 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
ST3GAL6Type 2 lactosamine alpha-2,3-sialyltransferase; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). Belongs to the glycosyltransferase 29 family. (384 aa)
FUT94-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth. Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lacto [...] (359 aa)
EPCAMEPCAM isoform 1. (338 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
FUT1Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. Belongs to the glycosyltransferase 11 family. (366 aa)
CD24CD24 isoform 8. (129 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LOC107968591CD24 isoform 1. (80 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
GALNT14Polypeptide N-acetylgalactosaminyltransferase. (557 aa)
LIFRLeukemia inhibitory factor receptor alpha. (1097 aa)
GLI1GLI family zinc finger 1. (1106 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LMO2LIM domain only 2. (228 aa)
CCNA1CCNA1 isoform 3; Belongs to the cyclin family. (421 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
PAX6PAX6 isoform 13. (436 aa)
OGAMeningioma expressed antigen 5 (Hyaluronidase). (946 aa)
GALNT6Polypeptide N-acetylgalactosaminyltransferase. (622 aa)
APOBAPOB isoform 1. (4562 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
GMDSGDP-mannose 4,6-dehydratase. (372 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
ST6GAL1ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
MGAT5Mannosyl (Alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase. (741 aa)
GALNT1Polypeptide N-acetylgalactosaminyltransferase. (559 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
B4GALT3UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3. (393 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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