STRINGSTRING
YY1 YY1 SIRT1-2 SIRT1-2 STAT2 STAT2 STAT3 STAT3 STAT1 STAT1 EZH2-2 EZH2-2 LOC742651 LOC742651 STAT5B STAT5B NEDD4 NEDD4 LOC741747 LOC741747 IFNA8 IFNA8 DDB1 DDB1 CK820_G0014527 CK820_G0014527 STAT4 STAT4 SMC6 SMC6 NR2F2 NR2F2 HDAC1 HDAC1 IFNA14 IFNA14 IFNA17 IFNA17 NUP153 NUP153 SIRT3 SIRT3 TLR8 TLR8 IFNA6 IFNA6 SETDB1 SETDB1 TLR7 TLR7 RXRA RXRA TRIM22 TRIM22 AP1G2 AP1G2 SMC5 SMC5 DDX58 DDX58 IFNA5 IFNA5 IFNA2 IFNA2 IFNA21 IFNA21 TDP2 TDP2 CCR5 CCR5 KAT2B KAT2B CAV3 CAV3 PPARA PPARA EP300 EP300 APOBEC3G APOBEC3G APOBEC3A APOBEC3A LIG1 LIG1 STAT5A STAT5A KAT2A KAT2A SP1 SP1 SLC10A1 SLC10A1 NR2C1 NR2C1 STAT6 STAT6 CDA CDA SIRT1 SIRT1 FEN1 FEN1 LTBR LTBR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YY1YY1 transcription factor. (414 aa)
SIRT1-2Sirtuin 1. (751 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
LOC742651IFNA1 isoform 1. (195 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
LOC741747IFNA7 isoform 1. (189 aa)
IFNA8Interferon alpha 8. (189 aa)
DDB1Damage-specific DNA binding protein 1, 127kDa. (1147 aa)
CK820_G0014527IFNA13 isoform 2. (198 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
SMC6Structural maintenance of chromosomes 6. (1160 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
IFNA14Interferon alpha 14. (189 aa)
IFNA17IFNA17 isoform 1. (189 aa)
NUP153NUP153 isoform 1. (1506 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
TLR8TLR8 isoform 2; Belongs to the Toll-like receptor family. (1059 aa)
IFNA6Interferon alpha 6. (190 aa)
SETDB1SETDB1 isoform 4. (1292 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
RXRARetinoid X receptor, alpha. (462 aa)
TRIM22Tripartite motif containing 22. (498 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
SMC5Structural maintenance of chromosomes 5. (1101 aa)
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (925 aa)
IFNA5Interferon alpha 5. (189 aa)
IFNA2IFNA2 isoform 1. (170 aa)
IFNA21Interferon alpha 21. (189 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (362 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
EP300E1A binding protein p300. (2175 aa)
APOBEC3GDNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs) and also against simian foamy virus (SFV). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hy [...] (384 aa)
APOBEC3AApolipoprotein B mRNA editing enzyme catalytic subunit 3B. (490 aa)
LIG1DNA ligase. (919 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
SP1Sp1 transcription factor. (786 aa)
SLC10A1Solute carrier family 10 member 1. (349 aa)
NR2C1Nuclear receptor subfamily 2, group C, member 1. (604 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
SIRT1SIRT1 isoform 2. (751 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LTBRLymphotoxin beta receptor (TNFR superfamily, member 3). (435 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.