STRINGSTRING
CTSB CTSB PDIA4 PDIA4 AGR2 AGR2 EDN1 EDN1 BMP6 BMP6 ATF4 ATF4 PDILT PDILT ARG2 ARG2 TMX1 TMX1 ERP29 ERP29 PDIA4-2 PDIA4-2 IDH1 IDH1 BLOC1S5 BLOC1S5 AGR3 AGR3 INS INS TXNDC12 TXNDC12 CASQ2 CASQ2 CASQ1 CASQ1 ATF6 ATF6 ADIPOR1 ADIPOR1 ADM ADM PRDX5 PRDX5 MMP1 MMP1 ERP27 ERP27 AR AR PDIA6 PDIA6 SRXN1 SRXN1 GLRX GLRX TNF TNF EGFR EGFR PDIA5 PDIA5 ITGB3 ITGB3 LOC100616026 LOC100616026 KLRD1 KLRD1 ADAM17 ADAM17 PDIA3 PDIA3 ADIPOR2 ADIPOR2 DDIT3 DDIT3 GPX7 GPX7 NR4A1 NR4A1 TXN TXN ERP44 ERP44 GSR GSR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTSBCTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
PDIA4Protein disulfide-isomerase A4. (645 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
EDN1EDN1 isoform 1. (212 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
PDILTPDILT isoform 1. (584 aa)
ARG2Arginase. (354 aa)
TMX1Thioredoxin-related transmembrane protein 1. (280 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
PDIA4-2Protein disulfide isomerase family A member 4. (645 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (424 aa)
BLOC1S5Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (220 aa)
AGR3Anterior gradient 3, protein disulphide isomerase family member. (166 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
TXNDC12Thioredoxin domain containing 12 (Endoplasmic reticulum). (172 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
ATF6Activating transcription factor 6. (670 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
ADMAdrenomedullin. (185 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
MMP1Matrix metallopeptidase 1 (Interstitial collagenase). (469 aa)
ERP27Endoplasmic reticulum protein 27. (273 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
PDIA6PDIA6 isoform 2; Belongs to the protein disulfide isomerase family. (489 aa)
SRXN1Sulfiredoxin. (165 aa)
GLRXGlutaredoxin (Thioltransferase). (106 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PDIA5Protein disulfide isomerase family A member 5. (519 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
LOC100616026Thioredoxin-like. (106 aa)
KLRD1Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
ADAM17ADAM17 isoform 3. (999 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (187 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
ERP44Endoplasmic reticulum protein 44. (406 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (522 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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