STRINGSTRING
IGF1 IGF1 FGF2 FGF2 HOPX HOPX PAX6 PAX6 GFAP GFAP SOX1 SOX1 RORB RORB EMX1 EMX1 RELN RELN WNT2B WNT2B FOXG1 FOXG1 POMC POMC ASPM ASPM PTPRZ1 PTPRZ1 SOX2 SOX2 MDGA1 MDGA1 TBR1 TBR1 SOX6 SOX6 SOX10 SOX10 DLX1 DLX1 PLP1 PLP1 NPY NPY DLL1 DLL1 ISL1 ISL1 OXT OXT GAD1 GAD1 OTX1 OTX1 NOG NOG KATNB1 KATNB1 OTX2 OTX2 MYRF MYRF NES NES PITX3 PITX3 CELF4 CELF4 PTEN PTEN CUX1 CUX1 FOXA2 FOXA2 CHRD CHRD SLC13A4 SLC13A4 TTR TTR SATB2 SATB2 INS INS NOTCH2 NOTCH2 SHH SHH CXCR4 CXCR4 FAM107A FAM107A OLIG2 OLIG2 KCNIP2 KCNIP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
HOPXHOPX isoform 3. (112 aa)
PAX6PAX6 isoform 13. (436 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
SOX1SOX1 isoform 1. (391 aa)
RORBRAR related orphan receptor B. (482 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
RELNRELN isoform 3. (3460 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
FOXG1FOXG1 isoform 8. (489 aa)
POMCProopiomelanocortin. (268 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2315 aa)
SOX2SRY-box transcription factor 2. (319 aa)
MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1. (955 aa)
TBR1T-box brain transcription factor 1. (682 aa)
SOX6SOX6 isoform 9. (828 aa)
SOX10SRY-box transcription factor 10. (466 aa)
DLX1Distal-less homeobox 1. (255 aa)
PLP1Proteolipid protein 1. (277 aa)
NPYNeuropeptide Y. (97 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
ISL1ISL LIM homeobox 1. (349 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (594 aa)
OTX1Orthodenticle homeobox 1. (354 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (655 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
MYRFMYRF isoform 2. (932 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
PITX3Homeobox protein. (302 aa)
CELF4CUGBP Elav-like family member 4. (486 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CUX1Homeobox protein cut-like. (1515 aa)
FOXA2FOXA2 isoform 1. (464 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
SLC13A4SLC13A4 isoform 2. (626 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
SATB2DNA-binding protein SATB. (733 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
FAM107AActin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal [...] (175 aa)
OLIG2OLIG2 isoform 1. (323 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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