30 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA4	GATA binding protein 4. (443 aa)
	GRIK2	Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	LOC112209457	HIST1H3A isoform 1. (136 aa)
	EDN1	EDN1 isoform 1. (212 aa)
	HIST1H3A	H3F3B isoform 13. (136 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	SIX3	SIX homeobox 3. (331 aa)
	CNP	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
	OTX2	Orthodenticle homeobox 2. (297 aa)
	ARID2	AT-rich interaction domain 2. (1835 aa)
	NES	NES isoform 1; Belongs to the intermediate filament family. (1620 aa)
	H3-4	HIST3H3 isoform 1. (136 aa)
	H3C13	HIST2H3A isoform 1. (136 aa)
	YBX1	YBX1 isoform 3. (295 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
	LOC107966300	Histone H3. (136 aa)
	SLIT2	Slit guidance ligand 2. (1542 aa)
	ARID1A	AT rich interactive domain 1A (SWI-like). (2287 aa)
	PAX5	PAX5 isoform 1. (391 aa)
	SOX4	Transcription factor SOX. (474 aa)
	FOXG1	FOXG1 isoform 8. (489 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	ALB	ALB isoform 2. (609 aa)
	RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit. (548 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	ZIC1	Zic family member 1. (447 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSPTRP00000058292	ENSPTRP00000056218	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	ALB isoform 2.	0.755
ACTB	ARID1A	ENSPTRP00000058292	ENSPTRP00000086363	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	AT rich interactive domain 1A (SWI-like).	0.979
ACTB	ARID2	ENSPTRP00000058292	ENSPTRP00000008299	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	AT-rich interaction domain 2.	0.960
ACTB	H3-4	ENSPTRP00000058292	ENSPTRP00000002098	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	HIST3H3 isoform 1.	0.741
ACTB	H3C13	ENSPTRP00000058292	ENSPTRP00000048353	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	HIST2H3A isoform 1.	0.612
ACTB	HIST1H3A	ENSPTRP00000058292	ENSPTRP00000021631	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	H3F3B isoform 13.	0.741
ACTB	INS	ENSPTRP00000058292	ENSPTRP00000077843	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.555
ACTB	LOC107966300	ENSPTRP00000058292	ENSPTRP00000078706	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Histone H3.	0.612
ACTB	LOC112209457	ENSPTRP00000058292	ENSPTRP00000030412	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	HIST1H3A isoform 1.	0.556
ACTB	NES	ENSPTRP00000058292	ENSPTRP00000002483	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	NES isoform 1; Belongs to the intermediate filament family.	0.430
ALB	ACTB	ENSPTRP00000056218	ENSPTRP00000058292	ALB isoform 2.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.755
ALB	EDN1	ENSPTRP00000056218	ENSPTRP00000030273	ALB isoform 2.	EDN1 isoform 1.	0.469
ALB	H3-4	ENSPTRP00000056218	ENSPTRP00000002098	ALB isoform 2.	HIST3H3 isoform 1.	0.558
ALB	INS	ENSPTRP00000056218	ENSPTRP00000077843	ALB isoform 2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.799
ALB	NES	ENSPTRP00000056218	ENSPTRP00000002483	ALB isoform 2.	NES isoform 1; Belongs to the intermediate filament family.	0.469
ALB	PAX6	ENSPTRP00000056218	ENSPTRP00000065705	ALB isoform 2.	PAX6 isoform 13.	0.472
ARID1A	ACTB	ENSPTRP00000086363	ENSPTRP00000058292	AT rich interactive domain 1A (SWI-like).	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.979
ARID1A	ARID2	ENSPTRP00000086363	ENSPTRP00000008299	AT rich interactive domain 1A (SWI-like).	AT-rich interaction domain 2.	0.910
ARID1A	H3-4	ENSPTRP00000086363	ENSPTRP00000002098	AT rich interactive domain 1A (SWI-like).	HIST3H3 isoform 1.	0.433
ARID1A	HIST1H3A	ENSPTRP00000086363	ENSPTRP00000021631	AT rich interactive domain 1A (SWI-like).	H3F3B isoform 13.	0.615