39 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LHX3	LHX3 isoform 2. (402 aa)
	S100A10	S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
	NES	NES isoform 1; Belongs to the intermediate filament family. (1620 aa)
	FOXO1	FOXO1 isoform 1. (655 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	LXN	LXN isoform 1. (222 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	LIX1	LIX1 isoform 1. (282 aa)
	GPR6	G protein-coupled receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	HOXA7	Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (230 aa)
	NEUROD6	Neurogenic differentiation factor. (337 aa)
	KLF4	Kruppel-like factor 4 (Gut). (479 aa)
	LHX2	LHX2 isoform 1. (406 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	EN1	Homeobox protein engrailed-like. (396 aa)
	FOXG1	FOXG1 isoform 8. (489 aa)
	UNC5D	Unc-5 netrin receptor D. (958 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
	RORB	RAR related orphan receptor B. (482 aa)
	ENSPTRP00000065099	annotation not available (337 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	DCX	DCX isoform 5. (420 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
	EN2	Engrailed homeobox 2. (338 aa)
	FOXP2	Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (741 aa)
	EN2-2	Homeobox protein engrailed-like. (336 aa)
	OMA1	OMA1 isoform 2. (420 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	CYP39A1	Cytochrome P450, family 39, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (471 aa)
	SATB2	DNA-binding protein SATB. (733 aa)
	LDB2	LIM domain binding 2. (373 aa)
	HOXA7-2	Homeobox A7. (230 aa)
	CUX2	Homeobox protein cut-like. (1489 aa)
	CRIM1	CRIM1 isoform 1. (1036 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	CUX1	Homeobox protein cut-like. (1515 aa)
	PAX2	PAX2 isoform 1. (417 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	DCX	ENSPTRP00000060385	ENSPTRP00000067534	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	DCX isoform 5.	0.590
BDNF	FGF2	ENSPTRP00000060385	ENSPTRP00000067812	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.	0.724
BDNF	GDNF	ENSPTRP00000060385	ENSPTRP00000048206	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Glial cell derived neurotrophic factor.	0.835
BDNF	NES	ENSPTRP00000060385	ENSPTRP00000002483	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	NES isoform 1; Belongs to the intermediate filament family.	0.605
BDNF	PAX6	ENSPTRP00000060385	ENSPTRP00000065705	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	PAX6 isoform 13.	0.484
BDNF	SOX2	ENSPTRP00000060385	ENSPTRP00000046752	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	SRY-box transcription factor 2.	0.461
CRIM1	CUX1	ENSPTRP00000090072	ENSPTRP00000090655	CRIM1 isoform 1.	Homeobox protein cut-like.	0.420
CRIM1	CUX2	ENSPTRP00000090072	ENSPTRP00000089985	CRIM1 isoform 1.	Homeobox protein cut-like.	0.562
CRIM1	EN1	ENSPTRP00000090072	ENSPTRP00000049224	CRIM1 isoform 1.	Homeobox protein engrailed-like.	0.433
CRIM1	EN2	ENSPTRP00000090072	ENSPTRP00000071578	CRIM1 isoform 1.	Engrailed homeobox 2.	0.441
CRIM1	EN2-2	ENSPTRP00000090072	ENSPTRP00000073091	CRIM1 isoform 1.	Homeobox protein engrailed-like.	0.441
CRIM1	FOXO1	ENSPTRP00000090072	ENSPTRP00000009886	CRIM1 isoform 1.	FOXO1 isoform 1.	0.423
CRIM1	GPR6	ENSPTRP00000090072	ENSPTRP00000031583	CRIM1 isoform 1.	G protein-coupled receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.487
CRIM1	ISL1	ENSPTRP00000090072	ENSPTRP00000028882	CRIM1 isoform 1.	ISL LIM homeobox 1.	0.547
CRIM1	LDB2	ENSPTRP00000090072	ENSPTRP00000080960	CRIM1 isoform 1.	LIM domain binding 2.	0.788
CRIM1	LHX2	ENSPTRP00000090072	ENSPTRP00000036487	CRIM1 isoform 1.	LHX2 isoform 1.	0.510
CRIM1	LHX3	ENSPTRP00000090072	ENSPTRP00000063429	CRIM1 isoform 1.	LHX3 isoform 2.	0.544
CRIM1	LIX1	ENSPTRP00000090072	ENSPTRP00000029276	CRIM1 isoform 1.	LIX1 isoform 1.	0.692
CRIM1	LXN	ENSPTRP00000090072	ENSPTRP00000026801	CRIM1 isoform 1.	LXN isoform 1.	0.775
CRIM1	MEF2C	ENSPTRP00000090072	ENSPTRP00000090496	CRIM1 isoform 1.	Myocyte enhancer factor 2C.	0.488