STRINGSTRING
ALB ALB MTOR MTOR RET RET IL18 IL18 FURIN FURIN IGF1R IGF1R COL1A1 COL1A1 RHOA RHOA UCP1 UCP1 GFRAL GFRAL GDNF GDNF ATF3 ATF3 RPS6 RPS6 KLF5 KLF5 SMAD2 SMAD2 CDK2 CDK2 IGF1 IGF1 EGFR EGFR CSF1 CSF1 LEP LEP ACTA2 ACTA2 FOXM1 FOXM1 EZH2 EZH2 INS INS CASP1 CASP1 TIMP1 TIMP1 EGR1 EGR1 CCND1 CCND1 EZH2-2 EZH2-2 SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALBALB isoform 2. (609 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
RHOARas homolog family member A. (193 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
GFRALGDNF family receptor alpha like. (394 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
ATF3Activating transcription factor 3. (181 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CDK2CDK2 isoform 4; Belongs to the protein kinase superfamily. (346 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
ACTA2ACTA2 isoform 1; Belongs to the actin family. (413 aa)
FOXM1FOXM1 isoform 4. (787 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
CASP1CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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