node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTN3A3 | CD1D | ENSPTRP00000030422 | ENSPTRP00000060660 | Butyrophilin subfamily 3 member A3. | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | 0.421 |
CD1D | BTN3A3 | ENSPTRP00000060660 | ENSPTRP00000030422 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | Butyrophilin subfamily 3 member A3. | 0.421 |
CD1D | CD38 | ENSPTRP00000060660 | ENSPTRP00000027436 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | CD38 isoform 1. | 0.472 |
CD1D | CD4 | ENSPTRP00000060660 | ENSPTRP00000054833 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.782 |
CD1D | GZMB | ENSPTRP00000060660 | ENSPTRP00000087293 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | GZMB isoform 2; Belongs to the peptidase S1 family. | 0.478 |
CD1D | IFNG | ENSPTRP00000060660 | ENSPTRP00000008822 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | 0.769 |
CD1D | IL2 | ENSPTRP00000060660 | ENSPTRP00000028193 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.580 |
CD1D | KLRD1 | ENSPTRP00000060660 | ENSPTRP00000057110 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | 0.443 |
CD1D | KLRK1 | ENSPTRP00000060660 | ENSPTRP00000007992 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] | 0.620 |
CD1D | TNF | ENSPTRP00000060660 | ENSPTRP00000069905 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.573 |
CD38 | CD1D | ENSPTRP00000027436 | ENSPTRP00000060660 | CD38 isoform 1. | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | 0.472 |
CD38 | CD4 | ENSPTRP00000027436 | ENSPTRP00000054833 | CD38 isoform 1. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.895 |
CD38 | CTLA4 | ENSPTRP00000027436 | ENSPTRP00000080210 | CD38 isoform 1. | Cytotoxic T-lymphocyte associated protein 4. | 0.657 |
CD38 | EOMES | ENSPTRP00000027436 | ENSPTRP00000025366 | CD38 isoform 1. | EOMES isoform 2. | 0.421 |
CD38 | GZMB | ENSPTRP00000027436 | ENSPTRP00000087293 | CD38 isoform 1. | GZMB isoform 2; Belongs to the peptidase S1 family. | 0.700 |
CD38 | IFNG | ENSPTRP00000027436 | ENSPTRP00000008822 | CD38 isoform 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | 0.694 |
CD38 | IL2 | ENSPTRP00000027436 | ENSPTRP00000028193 | CD38 isoform 1. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.594 |
CD38 | KLRC1 | ENSPTRP00000027436 | ENSPTRP00000059579 | CD38 isoform 1. | NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | 0.414 |
CD38 | KLRK1 | ENSPTRP00000027436 | ENSPTRP00000007992 | CD38 isoform 1. | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] | 0.448 |
CD38 | TIGIT | ENSPTRP00000027436 | ENSPTRP00000026290 | CD38 isoform 1. | TIGIT isoform 1. | 0.526 |