22 items (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

gene neighborhood

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Your Input:
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
	EMX2	Empty spiracles homeobox 2. (252 aa)
	DSCAML1	DS cell adhesion molecule like 1. (2113 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	GBX2	Gastrulation brain homeobox 2. (348 aa)
	ITPR1	ITPR1 isoform 3. (2700 aa)
	HARS1	HARS isoform 1. (509 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1. (955 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	EN1	Homeobox protein engrailed-like. (396 aa)
	RORB	RAR related orphan receptor B. (482 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	POU3F3	POU domain protein. (476 aa)
	ETV1	ETV1 isoform 11. (511 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	S100B	S100 calcium binding protein B; Belongs to the S-100 family. (94 aa)
	ETV1-2	ETS variant 1. (506 aa)
	CUX1	Homeobox protein cut-like. (1515 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	FGF17	ENSPTRP00000060385	ENSPTRP00000042446	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.527
BDNF	GAPDH	ENSPTRP00000060385	ENSPTRP00000007822	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.544
BDNF	ITPR1	ENSPTRP00000060385	ENSPTRP00000025124	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	ITPR1 isoform 3.	0.457
BDNF	PAX6	ENSPTRP00000060385	ENSPTRP00000065705	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	PAX6 isoform 13.	0.484
BDNF	SHH	ENSPTRP00000060385	ENSPTRP00000075730	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.568
BDNF	SOX2	ENSPTRP00000060385	ENSPTRP00000046752	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	SRY-box transcription factor 2.	0.461
CUX1	HARS1	ENSPTRP00000090655	ENSPTRP00000029618	Homeobox protein cut-like.	HARS isoform 1.	0.455
CUX1	PAX6	ENSPTRP00000090655	ENSPTRP00000065705	Homeobox protein cut-like.	PAX6 isoform 13.	0.540
CUX1	RORB	ENSPTRP00000090655	ENSPTRP00000060490	Homeobox protein cut-like.	RAR related orphan receptor B.	0.441
CUX1	SOX2	ENSPTRP00000090655	ENSPTRP00000046752	Homeobox protein cut-like.	SRY-box transcription factor 2.	0.664
CUX1	TBR1	ENSPTRP00000090655	ENSPTRP00000046292	Homeobox protein cut-like.	T-box brain transcription factor 1.	0.706
EMX2	FGF17	ENSPTRP00000005259	ENSPTRP00000042446	Empty spiracles homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
EMX2	SHH	ENSPTRP00000005259	ENSPTRP00000075730	Empty spiracles homeobox 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.513
EMX2	SOX2	ENSPTRP00000005259	ENSPTRP00000046752	Empty spiracles homeobox 2.	SRY-box transcription factor 2.	0.497
EMX2	TBR1	ENSPTRP00000005259	ENSPTRP00000046292	Empty spiracles homeobox 2.	T-box brain transcription factor 1.	0.605
EN1	PAX6	ENSPTRP00000049224	ENSPTRP00000065705	Homeobox protein engrailed-like.	PAX6 isoform 13.	0.542
EN1	RORB	ENSPTRP00000049224	ENSPTRP00000060490	Homeobox protein engrailed-like.	RAR related orphan receptor B.	0.461
EN1	SHH	ENSPTRP00000049224	ENSPTRP00000075730	Homeobox protein engrailed-like.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.490
ETV1	RORB	ENSPTRP00000075577	ENSPTRP00000060490	ETV1 isoform 11.	RAR related orphan receptor B.	0.417
ETV1-2	RORB	ENSPTRP00000082085	ENSPTRP00000060490	ETS variant 1.	RAR related orphan receptor B.	0.417