43 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

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	NES	NES isoform 1; Belongs to the intermediate filament family. (1620 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	GPSM2	G-protein-signaling modulator 2. (684 aa)
	RBM15	RNA binding motif protein 15. (977 aa)
	VIM	Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
	LUM	LUM isoform 1. (338 aa)
	FOXN4	FOXN4 isoform 2. (517 aa)
	KCNK10	Potassium two pore domain channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (543 aa)
	ARHGAP11A	ARHGAP11B isoform 3. (1023 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	ETV4	ETV4 isoform 3. (484 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	DAG1	Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (428 aa)
	HAPLN1	Hyaluronan and proteoglycan link protein 1. (354 aa)
	MARCKS	Myristoylated alanine-rich protein kinase C substrate. (332 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	CDH6	Cadherin 6, type 2, K-cadherin (Fetal kidney); Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	PTPRZ1	Protein tyrosine phosphatase receptor type Z1. (2315 aa)
	ASPM	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
	EMX1	Empty spiracles homeobox 1. (290 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	AFDN	Afadin, adherens junction formation factor. (1834 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	FGFR1	Fibroblast growth factor receptor. (854 aa)
	HOPX	HOPX isoform 3. (112 aa)
	FAM107A	Actin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal [...] (175 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	HP1BP3	Heterochromatin protein 1, binding protein 3. (553 aa)
	CDC42	Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
	PDGFD	Platelet derived growth factor D. (370 aa)
	LIFR	Leukemia inhibitory factor receptor alpha. (1097 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	SATB2	DNA-binding protein SATB. (733 aa)
	TMEM14B	T0060485 isoform 1. (151 aa)
	NEUROG2	NEUROG2 isoform 1. (272 aa)
	GPR161	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family. (543 aa)
	FGFR3	Fibroblast growth factor receptor. (808 aa)
	CDH11	Cadherin 11, type 2, OB-cadherin (Osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (811 aa)
	TRNP1	TMF1-regulated nuclear protein 1. (227 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	CDH11	ENSPTRP00000061867	ENSPTRP00000089421	Afadin, adherens junction formation factor.	Cadherin 11, type 2, OB-cadherin (Osteoblast); Cadherins are calcium-dependent cell adhesion proteins.	0.414
AFDN	GPSM2	ENSPTRP00000061867	ENSPTRP00000001792	Afadin, adherens junction formation factor.	G-protein-signaling modulator 2.	0.649
ARHGAP11A	ASPM	ENSPTRP00000011730	ENSPTRP00000051373	ARHGAP11B isoform 3.	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	0.857
ARHGAP11A	SATB2	ENSPTRP00000011730	ENSPTRP00000080249	ARHGAP11B isoform 3.	DNA-binding protein SATB.	0.448
ARHGAP11A	TRNP1	ENSPTRP00000011730	ENSPTRP00000090602	ARHGAP11B isoform 3.	TMF1-regulated nuclear protein 1.	0.428
ARL13B	GPR161	ENSPTRP00000026120	ENSPTRP00000088450	ADP ribosylation factor like GTPase 13B.	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family.	0.698
ARL13B	SHH	ENSPTRP00000026120	ENSPTRP00000075730	ADP ribosylation factor like GTPase 13B.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.612
ARL13B	SMO	ENSPTRP00000026120	ENSPTRP00000033707	ADP ribosylation factor like GTPase 13B.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.467
ASPM	ARHGAP11A	ENSPTRP00000051373	ENSPTRP00000011730	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	ARHGAP11B isoform 3.	0.857
ASPM	PAX6	ENSPTRP00000051373	ENSPTRP00000065705	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	PAX6 isoform 13.	0.446
ASPM	PDGFD	ENSPTRP00000051373	ENSPTRP00000077954	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Platelet derived growth factor D.	0.459
ASPM	SHH	ENSPTRP00000051373	ENSPTRP00000075730	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.667
ASPM	SOX2	ENSPTRP00000051373	ENSPTRP00000046752	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	SRY-box transcription factor 2.	0.453
BMP7	SHH	ENSPTRP00000023489	ENSPTRP00000075730	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.648
CDC42	FGFR1	ENSPTRP00000077648	ENSPTRP00000065828	Cell division cycle 42 (GTP binding protein, 25kDa).	Fibroblast growth factor receptor.	0.500
CDC42	IQGAP1	ENSPTRP00000077648	ENSPTRP00000012743	Cell division cycle 42 (GTP binding protein, 25kDa).	IQ motif containing GTPase activating protein 1.	0.999
CDC42	MTOR	ENSPTRP00000077648	ENSPTRP00000000280	Cell division cycle 42 (GTP binding protein, 25kDa).	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.451
CDC42	PDGFRB	ENSPTRP00000077648	ENSPTRP00000080188	Cell division cycle 42 (GTP binding protein, 25kDa).	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.430
CDC42	PTEN	ENSPTRP00000077648	ENSPTRP00000090779	Cell division cycle 42 (GTP binding protein, 25kDa).	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.588
CDC42	STAT3	ENSPTRP00000077648	ENSPTRP00000091410	Cell division cycle 42 (GTP binding protein, 25kDa).	Signal transducer and activator of transcription.	0.487