STRINGSTRING
AQP3 AQP3 RYR3 RYR3 TRPM3 TRPM3 GPHN GPHN CNGA1 CNGA1 TRPM6 TRPM6 TRPV5 TRPV5 TRPV4 TRPV4 TRPC1 TRPC1 RIC3 RIC3 SRI-2 SRI-2 ANO2 ANO2 SRI SRI UNC80 UNC80 CNGA3 CNGA3 ENSPTRP00000079594 ENSPTRP00000079594 CNGA2-2 CNGA2-2 ANO1 ANO1 SRC SRC GRIK4 GRIK4 PIEZO2 PIEZO2 TRPM8 TRPM8 BEST1 BEST1 TRPM1 TRPM1 GRIN2A GRIN2A TRPC3 TRPC3 REN REN TTYH1 TTYH1 PKD2L2 PKD2L2 TRPA1 TRPA1 NUDT9 NUDT9 TRPC4 TRPC4 TRPV6 TRPV6 SLC26A3 SLC26A3 LRRC8B LRRC8B LRRC8A LRRC8A KCNQ3 KCNQ3 TRPV5-2 TRPV5-2 CAV1 CAV1 OSTM1 OSTM1 CLIC1 CLIC1 GRM6 GRM6 CATSPER3 CATSPER3 CNGA1-2 CNGA1-2 RHO RHO CAV3 CAV3 TRPM4 TRPM4 BEST2 BEST2 LRRC8E LRRC8E TRPV2 TRPV2 TRPV1 TRPV1 TRPV3 TRPV3 PIEZO1 PIEZO1 HCN4 HCN4 TRPM7 TRPM7 UNC79 UNC79 NALCN NALCN NTS NTS BEST3 BEST3 AQP6 AQP6 PANX1 PANX1 AQP11 AQP11 CATSPER1 CATSPER1 PKD2L1 PKD2L1 GLUD1 GLUD1 CASQ1 CASQ1 CASQ2 CASQ2 LRRC8C LRRC8C BEST4 BEST4 CATSPER4 CATSPER4 CLIC4 CLIC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
RYR3Ryanodine receptor 3. (4873 aa)
TRPM3Transient receptor potential cation channel subfamily M member 3. (1711 aa)
GPHNMolybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (782 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (672 aa)
TRPM6TRPM6 isoform 2. (2017 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5. (732 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
RIC3RIC3 acetylcholine receptor chaperone. (369 aa)
SRI-2SRI isoform 5. (237 aa)
ANO2Anoctamin. (999 aa)
SRISRI isoform 1. (205 aa)
UNC80Unc-80 homolog, NALCN channel complex subunit. (3323 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (698 aa)
ENSPTRP00000079594annotation not available (460 aa)
CNGA2-2Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
ANO1Anoctamin. (986 aa)
SRCTyrosine-protein kinase. (542 aa)
GRIK4Glutamate receptor ionotropic, kainate 4; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). (959 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2777 aa)
TRPM8TRPM8 isoform 2. (1104 aa)
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (664 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1642 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
TTYH1Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (460 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (624 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
NUDT9Nudix (Nucleoside diphosphate linked moiety X)-type motif 9. (350 aa)
TRPC4Transient receptor potential cation channel, subfamily C, member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6. (765 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (762 aa)
LRRC8BLeucine rich repeat containing 8 VRAC subunit B. (803 aa)
LRRC8ALeucine rich repeat containing 8 family, member A. (810 aa)
KCNQ3KCNQ3 isoform 1; Belongs to the potassium channel family. (843 aa)
TRPV5-2Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
OSTM1Osteoclastogenesis associated transmembrane protein 1. (334 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
GRM6GRM6 isoform 2. (879 aa)
CATSPER3Cation channel sperm associated 3. (398 aa)
CNGA1-2Cyclic nucleotide gated channel subunit alpha 1. (759 aa)
RHORhodopsin. (348 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
BEST2Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (509 aa)
LRRC8ELeucine rich repeat containing 8 family, member E. (796 aa)
TRPV2Transient receptor potential cation channel, subfamily V, member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2516 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
TRPM7Transient receptor potential cation channel, subfamily M, member 7. (1865 aa)
UNC79UNC79 isoform 1. (2648 aa)
NALCNSodium leak channel, non-selective. (1738 aa)
NTSNTS isoform 1. (170 aa)
BEST3Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (668 aa)
AQP6AQP6 isoform 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (282 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
CATSPER1Cation channel sperm associated 1. (780 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (805 aa)
GLUD1Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
LRRC8CT0070613 isoform 1. (803 aa)
BEST4Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (473 aa)
CATSPER4Cation channel sperm associated 4. (464 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.