19 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DKK1	Dickkopf-like protein 1. (289 aa)
	CUX1	Homeobox protein cut-like. (1515 aa)
	REL	REL isoform 1. (619 aa)
	TTR	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	RELN	RELN isoform 3. (3460 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	FLRT1	Fibronectin leucine rich transmembrane protein 1. (674 aa)
	CK820_G0018745	FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (628 aa)
	LMX1B	LIM homeobox transcription factor 1 beta. (402 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	AXIN2	AXIN2 isoform 1. (843 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSPTRP00000016228	ENSPTRP00000010780	AXIN2 isoform 1.	Bone morphogenetic protein 4.	0.455
AXIN2	BMP4-2	ENSPTRP00000016228	ENSPTRP00000080656	AXIN2 isoform 1.	Bone morphogenetic protein 4.	0.455
AXIN2	CK820_G0018745	ENSPTRP00000016228	ENSPTRP00000040179	AXIN2 isoform 1.	FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.562
AXIN2	DKK1	ENSPTRP00000016228	ENSPTRP00000004327	AXIN2 isoform 1.	Dickkopf-like protein 1.	0.725
AXIN2	GAPDH	ENSPTRP00000016228	ENSPTRP00000007822	AXIN2 isoform 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.480
AXIN2	LEF1	ENSPTRP00000016228	ENSPTRP00000079959	AXIN2 isoform 1.	Lymphoid enhancer binding factor 1.	0.981
AXIN2	LRP5	ENSPTRP00000016228	ENSPTRP00000068813	AXIN2 isoform 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.823
AXIN2	SHH	ENSPTRP00000016228	ENSPTRP00000075730	AXIN2 isoform 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.484
AXIN2	WNT3A	ENSPTRP00000016228	ENSPTRP00000051074	AXIN2 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.833
BMP4	AXIN2	ENSPTRP00000010780	ENSPTRP00000016228	Bone morphogenetic protein 4.	AXIN2 isoform 1.	0.455
BMP4	DKK1	ENSPTRP00000010780	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4	LEF1	ENSPTRP00000010780	ENSPTRP00000079959	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.626
BMP4	PAX6	ENSPTRP00000010780	ENSPTRP00000065705	Bone morphogenetic protein 4.	PAX6 isoform 13.	0.475
BMP4	SHH	ENSPTRP00000010780	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4	WNT3A	ENSPTRP00000010780	ENSPTRP00000051074	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.708
BMP4-2	AXIN2	ENSPTRP00000080656	ENSPTRP00000016228	Bone morphogenetic protein 4.	AXIN2 isoform 1.	0.455
BMP4-2	DKK1	ENSPTRP00000080656	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4-2	LEF1	ENSPTRP00000080656	ENSPTRP00000079959	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.626
BMP4-2	PAX6	ENSPTRP00000080656	ENSPTRP00000065705	Bone morphogenetic protein 4.	PAX6 isoform 13.	0.475
BMP4-2	SHH	ENSPTRP00000080656	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720