STRINGSTRING
DKK1 DKK1 CUX1 CUX1 REL REL TTR TTR BMP4-2 BMP4-2 LEF1 LEF1 SHH SHH LRP5 LRP5 PAX6 PAX6 RELN RELN CASP3 CASP3 WNT3A WNT3A FLRT1 FLRT1 CK820_G0018745 CK820_G0018745 LMX1B LMX1B FLRT3 FLRT3 AXIN2 AXIN2 BMP4 BMP4 GAPDH GAPDH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DKK1Dickkopf-like protein 1. (289 aa)
CUX1Homeobox protein cut-like. (1515 aa)
RELREL isoform 1. (619 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
PAX6PAX6 isoform 13. (436 aa)
RELNRELN isoform 3. (3460 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
CK820_G0018745FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (628 aa)
LMX1BLIM homeobox transcription factor 1 beta. (402 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
AXIN2AXIN2 isoform 1. (843 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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