STRINGSTRING
TTR TTR DKK1 DKK1 GAPDH GAPDH BMP4 BMP4 AXIN2 AXIN2 FLRT3 FLRT3 LMX1B LMX1B CK820_G0018745 CK820_G0018745 FLRT1 FLRT1 WNT3A WNT3A CASP3 CASP3 RELN RELN PAX6 PAX6 LRP5 LRP5 SHH SHH LEF1 LEF1 BMP4-2 BMP4-2 REL REL CUX1 CUX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
DKK1Dickkopf-like protein 1. (289 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
AXIN2AXIN2 isoform 1. (843 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
LMX1BLIM homeobox transcription factor 1 beta. (402 aa)
CK820_G0018745FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (628 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
RELNRELN isoform 3. (3460 aa)
PAX6PAX6 isoform 13. (436 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
RELREL isoform 1. (619 aa)
CUX1Homeobox protein cut-like. (1515 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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