STRINGSTRING
ACTB ACTB VAMP2 VAMP2 ALB ALB CHAT CHAT MNX1 MNX1 SOX2 SOX2 TGFB3 TGFB3 MAP2 MAP2 KLF4 KLF4 SV2C SV2C ISL1 ISL1 NKX6-1 NKX6-1 SNAP25 SNAP25 TGFB1 TGFB1 SYT1 SYT1 CNTF CNTF NES NES SYT2 SYT2 TGFB2 TGFB2 RPS23 RPS23 ST3GAL2 ST3GAL2 ST3GAL3 ST3GAL3 PPIA PPIA SHH SHH VAMP1 VAMP1 OLIG2 OLIG2 FGF2 FGF2 SOX1 SOX1 BDNF BDNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
VAMP2VAMP2 isoform 3. (118 aa)
ALBALB isoform 2. (609 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (748 aa)
MNX1Motor neuron and pancreas homeobox 1. (398 aa)
SOX2SRY-box transcription factor 2. (319 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAP2Microtubule-associated protein. (1827 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
SV2CSynaptic vesicle glycoprotein 2C. (727 aa)
ISL1ISL LIM homeobox 1. (349 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; Belongs to the SNAP-25 family. (206 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SYT1Synaptotagmin 1. (422 aa)
CNTFCiliary neurotrophic factor. (200 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
SYT2Synaptotagmin 2. (419 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RPS23Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (143 aa)
ST3GAL2CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; Responsible for the synthesis of the sequence NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. (350 aa)
ST3GAL3CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal- beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta- 1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. (444 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
VAMP1Vesicle associated membrane protein 1. (118 aa)
OLIG2OLIG2 isoform 1. (323 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
SOX1SOX1 isoform 1. (391 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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