STRINGSTRING
TGFB2 TGFB2 PRKG1 PRKG1 XPO4 XPO4 TGFB3 TGFB3 SMAD4 SMAD4 SLC2A10 SLC2A10 CBS CBS MMUT MMUT NOTCH1 NOTCH1 COL5A2 COL5A2 MYH11 MYH11 FBN1 FBN1 TGFBR1 TGFBR1 COL5A1 COL5A1 ACTA2 ACTA2 TGFBR2 TGFBR2 MYLK MYLK SMAD3 SMAD3 FBN2 FBN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
XPO4XPO4 isoform 1. (1141 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SLC2A10Solute carrier family 2 (Facilitated glucose transporter), member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
MMUTMethylmalonyl CoA mutase. (750 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
MYH11MYH11 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
FBN1FBN1 isoform 1. (2871 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
COL5A1Collagen type V alpha 1 chain. (1841 aa)
ACTA2ACTA2 isoform 1; Belongs to the actin family. (413 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
MYLKMYLK isoform 12. (1919 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
FBN2FBN2 isoform 1. (2912 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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